Enhanced Skin Permeation and Controlled Release of Beta-Sitosterol Using Cubosomes Encrusted with Dissolving Microneedles for the Management of Alopecia

    April 2023 in “ Pharmaceuticals ”
    Kousalya Prabahar, Ubaidulla Uthumansha, Nehal M. Elsherbiny, Mona Qushawy
    Studysummary This study found that cubosomes combined with dissolving microneedles enhanced transdermal penetration and hair growth efficacy of beta-sitosterol for treating alopecia.
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    Research cited in this study 10

    1. Microneedle Mediated Transdermal Delivery of Beta-Sitosterol Loaded Nanostructured Lipid Nanoparticles for Androgenic Alopecia Drug Delivery · 2022
    2. Preparation and Optimization of Aloe Ferox Gel Loaded with Finasteride-Oregano Oil Nanocubosomes for Treatment of Alopecia Drug Delivery · 2022
    3. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    4. Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options Clinical and Experimental Medicine · 2021
    5. A Review on Hair Growth Regulators Journal of Drug Delivery and Therapeutics · 2020
    6. A Review on Finasteride: A 5-Alpha Reductase Inhibitor, Its Mechanism, Facts, and Benefits Journal of Drug Delivery and Therapeutics · 2019
    7. Sexual Problems of Men With Androgenic Alopecia Treated With 5-Alpha Reductase Inhibitors Sexual medicine reviews · 2018
    8. Clinical Cosmeceutical Repurposing of Melatonin in Androgenic Alopecia Using Nanostructured Lipid Carriers Prepared with Antioxidant Oils Expert Opinion on Drug Delivery · 2018
    9. Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol Medicines · 2016
    10. Development and Characterization of Phyto-Vesicles of Beta-Sitosterol for the Treatment of Androgenetic Alopecia Archives of Dermatological Research · 2011