Tremella Polysaccharide Microneedles Loaded With Magnetic Dental Pulp Stem Cell Intracellular Vesicles Used For Androgenic Alopecia

    March 2025 in “ Stem Cell Research & Therapy
    Yonghao Liu, Heng Zhou, Pengcheng Pang, Ye Liu, Jieying Situ, Junnan Wang, Yan He, Zhigang Cheng
    TLDR A new microneedle treatment could effectively regrow hair in androgenic alopecia.
    The study investigates a novel treatment for androgenic alopecia (AGA) using Tremella polysaccharide microneedles loaded with magnetic dental pulp stem cell intracellular vesicles (Mag-IVs). The microneedle system, which includes hyaluronic acid, aims to improve the hair follicle microenvironment by promoting angiogenesis, reducing inflammation, and protecting hair papillary cells from apoptosis. In vivo experiments on 42 male KM mice showed that this treatment significantly enhanced hair regeneration, with results comparable to Minoxidil. The findings suggest that this approach could offer a promising and minimally invasive alternative for AGA therapy, although further research is needed to address clinical translation challenges.
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