Platinum Nanozyme-Loaded Dissolving Microneedles Scavenge ROS and Promote Lineage Progression for Androgenetic Alopecia Treatment

    October 2024 in “ Small Methods ”
    Weitong Hu, Shuhan Shi, Yihua Xu … Jianqing Gao
    Studysummary This study found that dissolving microneedles loaded with platinum nanozymes induced faster hair growth in an androgenetic alopecia model than daily minoxidil applications, with no significant safety concerns.
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    Research cited in this study 20

    1. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    2. Regulation and Dysregulation of Hair Regeneration: Aiming for Clinical Application Cell Regeneration · 2022
    3. Dissolving Microneedles: Applications and Growing Therapeutic Potential Journal of Controlled Release · 2022
    4. Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model Acta Biomaterialia · 2022
    5. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    6. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    7. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020
    8. Mechanical Stretch Induces Hair Regeneration Through the Alternative Activation of Macrophages Nature Communications · 2019
    9. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019
    10. Off-Label Use of Topical Minoxidil in Alopecia: A Review American Journal of Clinical Dermatology · 2019
    11. GWAS for Male-Pattern Baldness Identifies 71 Susceptibility Loci Explaining 38% of the Risk Nature Communications · 2017
    12. Meta-Analysis Identifies Novel Risk Loci and Yields Systematic Insights into the Biology of Male-Pattern Baldness Nature communications · 2017
    13. Stress-Induced Premature Senescence of Dermal Papilla Cells Compromises Hair Follicle Epithelial-Mesenchymal Interaction Journal of Dermatological Science · 2017
    14. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    15. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
    16. Minoxidil Use in Dermatology, Side Effects, and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012
    17. Treatments for Androgenetic Alopecia and Alopecia Areata Drugs · 2001
    18. The Psychosocial Consequences of Androgenetic Alopecia: A Review of the Research Literature British Journal of Dermatology · 1999
    19. Drug-Induced Hair Loss and Hair Growth Drug Safety · 1994
    20. Topical Minoxidil for Hair Regrowth Journal of The American Academy of Dermatology · 1984