Platinum Nanozyme-Loaded Dissolving Microneedles Scavenge ROS and Promote Lineage Progression for Androgenetic Alopecia Treatment

The study explores the use of platinum nanozyme-loaded dissolving microneedles (Pt-MNs) as a treatment for androgenetic alopecia (AGA). These microneedles are designed to overcome the skin barrier and deliver platinum nanozymes (PtNZs) effectively. In an AGA model, Pt-MNs demonstrated the ability to reduce reactive oxygen species (ROS) and promote hair regeneration by enhancing oxidative phosphorylation and hair follicle stem cell differentiation. The treatment, administered once every three days, resulted in faster hair growth compared to daily minoxidil application. Safety tests confirmed that Pt-MNs create temporary skin channels without leaving platinum residues in major organs, suggesting a high safety profile. The study concludes that Pt-MNs have significant potential as an effective AGA treatment.