Regulation and Dysregulation of Hair Regeneration: Aiming for Clinical Application

July 2022 in “ Cell Regeneration ”

Zhicao Yue, Fang Yang, Jianglin Zhang, Ji Li, Cheng‐Ming Chuong

hair regeneration stem cells local growth factors immune signals neuroendocrine signals dietary factors environmental factors male pattern hair loss androgen signaling alopecia areata immune system hair follicle genome-wide association studies genetic bases macroenvironment hair growth immune response genetic studies

TLDR Understanding hair growth involves complex factors, and more research is needed to improve treatments for hair loss conditions.

The review "Regulation and dysregulation of hair regeneration: aiming for clinical application" discusses the complex factors influencing hair growth and regeneration, including stem cells, local growth factors, immune and neuroendocrine signals, and dietary and environmental factors. It highlights that in male pattern hair loss, stem cells are preserved but androgen signaling reduces hair growth, while in alopecia areata, the immune system attacks the hair follicle without eliminating its regeneration capability. The exact pathological mechanisms of these disorders are largely unknown despite genome-wide association studies revealing their genetic bases. The review emphasizes the importance of adjusting the macroenvironment for hair growth and regeneration, and the need for further research due to the complexity of these disorders and the limitations of current treatment options.

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6 citations , March 2021 in “Journal of Cosmetic Dermatology”

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research Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management

102 citations , January 2018 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

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research GWAS for Male-Pattern Baldness Identifies 71 Susceptibility Loci Explaining 38% of the Risk

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research Hunting the Genes in Male-Pattern Alopecia: How Important Are They, How Close Are We and What Will They Tell Us?

46 citations , April 2016 in “Experimental Dermatology”

Genes play a significant role in male-pattern baldness, and understanding them could lead to new treatments and insights into related health issues.

research The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells

46 citations , November 2015 in “Journal of Investigative Dermatology”

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305 citations , July 2012 in “Nature”

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87 citations , May 2012 in “PLOS Genetics”

Six new genetic regions linked to early hair loss also connect to Parkinson's disease and prostate cancer, possibly leading to new treatments.

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

421 citations , April 2012 in “The New England Journal of Medicine”

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59 citations , April 2012 in “Journal of Dermatological Science”

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205 citations , March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

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499 citations , September 2011 in “Cell”

Fat-related cells are important for initiating hair growth.

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176 citations , April 2011 in “Science”

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research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

235 citations , February 2011 in “Journal of Clinical Investigation”

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126 citations , April 2010 in “British Journal of Dermatology”

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VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

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4 / 4 results

research Alopecia Areata: A Multifactorial Autoimmune Condition

148 citations , March 2019 in “Journal of autoimmunity”

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236 citations , July 2001 in “Trends in Molecular Medicine”

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