TLDR Hair follicle stem cells rely on nearby blood vessels for their maintenance and function.
The study investigated the relationship between hair follicle stem cells and their perivascular microenvironment, focusing on K15- stem cells in the upper bulge of hair follicles in mouse skin. It found that these stem cells were consistently associated with a venous vascular annulus, which persisted throughout the hair cycle and even after denervation, indicating its crucial role in maintaining the stem cell niche. The angiogenic factor Egfl6, expressed by the K15- bulge, was localized near this annulus, suggesting its role in promoting angiogenesis and endothelial cell migration. The research highlighted the importance of the perivascular niche in regulating hair follicle stem cells and proposed that this microenvironment was essential for the specification and maintenance of upper bulge stem cells, with potential implications for tissue engineering and stem cell-based therapies. The study involved normal fetal and postnatal FVB mice, with three embryos analyzed at each time point.
138 citations
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February 2011 in “Cell” Nephronectin helps attach muscle cells to hair follicles.
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April 2010 in “Development” Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.
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March 2010 in “Journal of Cellular Biochemistry” Nestin-expressing blood vessels help skin transplants survive and heal.
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October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
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July 2006 in “Journal of Investigative Dermatology” Chemotherapy affects blood vessels in hair follicles, not stem cells, allowing hair regrowth.
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November 2005 in “Nature Medicine” 212 citations
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August 2004 in “Proceedings of the National Academy of Sciences” Hair follicle cells can create new blood vessels in the skin.
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March 2018 in “Pigment Cell & Melanoma Research” The environment around melanocyte stem cells is key for hair regeneration and color, with certain injuries affecting hair color and potential treatments for pigmentation disorders.
137 citations
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April 2015 in “Nature Reviews Molecular Cell Biology” Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.
Dermal stem cells help regenerate hair follicles and heal skin wounds.
1 citations
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October 2012 in “Elsevier eBooks” Skin stem cells can help improve skin repair and regeneration.
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December 2020 in “Frontiers in Cell and Developmental Biology” Gene network oscillations inside hair stem cells are key for hair growth regulation and could help treat hair loss.
