Compartmentalized Organization: A Common and Required Feature of Stem Cell Niches?

    April 2010 in “ Development ”
    Valentina Greco, Shangqin Guo
    Image of study
    TLDR Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.
    The document from May 15, 2010, explores the concept of compartmentalized organization within stem cell niches, using the hair follicle stem cell niche as a primary example. It suggests that this bi-compartmental organization, which separates immediate and long-term growth, may be a common feature in other adult stem cell niches, such as those in the blood, intestine, and brain. The hair follicle stem cell niche is described as having slow-cycling bulge cells for long-term growth and rapidly cycling hair germ cells for new growth. The document also discusses the presence of dormant and active hematopoietic stem cells in the bone marrow, Bmi1-positive cells and Lgr5+ crypt base columnar cells in the intestine, and two groups of astrocytes in the brain. It proposes that lineage tracing could be a useful tool to study these compartments in vivo. The document also addresses the limitations of Cre-recombinase-mediated lineage tracing, the influence of the niche environment on stem cell identity, and the potential interchangeability of stem cell states. It concludes that compartmentalized organization may be essential for stem cells to respond to growth or injury without depletion and acknowledges the need for rigorous experimental approaches to better understand the relationship between different compartments within stem cell niches.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Hair theory Scar tissue and Verteporfin

      in Chat  25 upvotes 5 months ago
      A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

      community Redensyl Megathread !!!!

       44 upvotes 4 years ago
      Redensyl, which is a topical alternative to Minoxidil for hair loss. It may have advantages such as not making the hair greasy and lasting longer after discontinuing use than minoxidil. There are some positive reports from users, but also some negative ones, so it's unclear how effective this treatment will be in comparison to Minoxidil and other treatments like Finasteride or RU58841.

      community A Nuanced Look at Microdosing Topical Finasteride

      in Finasteride/Dutasteride  85 upvotes 11 months ago
      The conversation discusses using a low dose of topical finasteride to achieve hair benefits with minimal systemic exposure. Users share experiences and opinions on dosing, systemic buildup, and side effects of both topical and oral finasteride.

      community Clearing the air on how non-surgical treatments really work

       18 upvotes 5 years ago
      Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

      community microneedle, any long term users damage?

      in Microneedling  35 upvotes 5 months ago
      Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

    Related Research

    1 / 1 results