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GlossaryHematopoietic Stem Cells

produce all types of blood cells in bone marrow

Hematopoietic Stem Cells (HSCs) are a type of stem cell found in the bone marrow that are responsible for producing all the different types of blood cells, including red blood cells, white blood cells, and platelets. These cells have the unique ability to both self-renew, creating more HSCs, and differentiate into various specialized blood cells, making them crucial for maintaining a healthy and functional blood system.

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research Identification of Transcripts Commonly Expressed in Both Hematopoietic and Germ-Line Stem Cells

14 citations , February 2008 in “Stem Cells and Development”

Seven genes are highly expressed in both germ-line and hematopoietic stem cells.

research Hematopoietic Stem Cells: Nature and Niche Nurture

2 citations , May 2021 in “Bioengineering”

Blood stem cells are diverse, influenced by many factors, and understanding them is key for progress in regenerative medicine.

research Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

695 citations , October 2011 in “Cell stem cell”

Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.

research Mice Engrafted with Human Fetal Thymic Tissue and Hematopoietic Stem Cells Develop Pathology Resembling Chronic Graft-Versus-Host Disease

47 citations , June 2013 in “Biology of blood and marrow transplantation”

Mice with human fetal thymic tissue and stem cells developed symptoms similar to chronic graft-versus-host disease.

research Stem Cells in the Body

November 2017

Stem cells regenerate tissues and their behavior varies by environment, suggesting the hematopoietic system model may need revision.

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Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.