Nestin-Expressing Interfollicular Blood Vessel Network Contributes to Skin Transplant Survival and Wound Healing

    March 2010 in “ Journal of Cellular Biochemistry ”
    Ryoichi Aki, Yasuyuki Amoh, Lingna Li, Kensei Katsuoka, Robert M. Hoffman
    TLDR Nestin-expressing blood vessels help skin transplants survive and heal.
    The study demonstrated that a network of blood vessels expressing nestin-driven green fluorescent protein (ND-GFP) played a crucial role in skin transplant survival and wound healing. Using ND-GFP transgenic mice, researchers observed that angiogenesis in transplanted skin or healing wounds originated from this microvasculature network, which appeared to stem from ND-GFP-expressing hair-follicle stem cells. The formation of chimeric ND-GFP-RFP blood vessels in experiments involving transplants between ND-GFP and RFP-expressing mice suggested the integration of blood vessel networks from both the transplant and host. These findings indicated that the inter-hair-follicle blood vessel network significantly contributed to the re-establishment of the dermal microvasculature after skin transplantation or injury.
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