Multipotent Hair Follicle Stem Cells Promote Repair of Spinal Cord Injury and Recovery of Walking Function

    June 2008 in “ Cell Cycle ”
    Yasuyuki Amoh, Lingna Li, Kensei Katsuoka, Robert M. Hoffman
    TLDR Hair follicle stem cells can help repair spinal cord injuries and improve walking.
    The study demonstrated that multipotent hair follicle stem cells from C57BL transgenic mice could promote the repair of spinal cord injuries and aid in the recovery of walking function. These stem cells, which were positive for stem cell markers nestin and CD34, but negative for keratin 15, were capable of differentiating into various cell types, including neurons and Schwann cells. When transplanted into the injury site of severed thoracic spinal cords in mice, the cells primarily differentiated into Schwann cells, facilitating the repair and reestablishment of hind-limb locomotor performance. The findings suggested that hair follicle stem cells could serve as an effective, accessible source for treating peripheral nerve and spinal cord injuries.
    Discuss this study in the Community →

    Research cited in this study

    8 / 8 results

    Related Community Posts Join

    6 / 1000+ results

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 2 years ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  140 upvotes 2 years ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community Please explain this Minoxidil phenomena

      in Minoxidil  57 upvotes 2 years ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

      community Best Microneedle Lengths To Stimulate Stem Cells

      in Microneedling  18 upvotes 2 years ago
      Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.

      community 22 yr asian male 2 year fin results

      in Progress Pictures  135 upvotes 2 years ago
      The user "Top_Replacement_7777" shared their positive results with finasteride for hair loss. They asked about maintaining their hair with finasteride and the impact of vaping on hair growth. Another user reassured them that vaping wouldn't affect their progress.

      community TDM-105795 phase 2 results are in!

      in Research/Science  29 upvotes 2 years ago
      TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

    Similar Research

    6 / 1000+ results