Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation

June 2019 in “ Tissue & Cell ”

Kyoumi Shirai, Koya Obara, Natsuko Tohgi, Aiko Yamazaki, Ryoichi Aki, Yuko Hamada, Nobuko Arakawa, Shree Ram Singh, Robert M. Hoffman, Yasuyuki Amoh

type-XVII collagen COL17A1 hair-follicle-associated pluripotent stem cells HAP stem cells nestin SSEA1 epidermal keratinocytes DNA-damage response proteolysis hair-follicle miniaturization androgenic alopecia

TLDR Hair stem cells produce a protein called COL17A1 that plays a key role in their development and is linked to hair thinning and baldness.

The 2019 study demonstrated that hair-follicle-associated pluripotent (HAP) stem cells, which reside in the upper part of the hair follicle, co-express nestin and type-XVII collagen (COL17A1). The expression of HAP stem cell markers (nestin and SSEA1) increased after HAP stem-cell colonies were formed, then decreased after differentiation to epidermal keratinocytes. In contrast, COL17A1 increased after differentiation to epidermal keratinocytes. This suggests that COL17A1 plays a significant role in the differentiation of HAP stem cells. The study also noted that the DNA-damage response in non-HAP hair follicle stem cells induces proteolysis of COL17A1, which is involved in hair-follicle stem-cell maintenance and is associated with hair-follicle miniaturization and androgenic alopecia.

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Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation

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Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation

Research cited in this study

research Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis

research Hypoxia Enhances Differentiation of Hair Follicle-Associated Pluripotent Stem Cells to Cardiac Muscle Cells

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research Isoproterenol Directs Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Differentiate In Vitro to Cardiac Muscle Cells Which Can Be Induced to Form Beating Heart-Muscle Tissue Sheets

research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

research From Hair to Heart: Nestin-Expressing Hair-Follicle-Associated Pluripotent Stem Cells Differentiate to Beating Cardiac Muscle Cells

research Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells

research Multipotent Hair Follicle Stem Cells Promote Repair of Spinal Cord Injury and Recovery of Walking Function

research Chemotherapy Targets the Hair Follicle Vascular Network but Not the Stem Cells

research Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves

research Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons

research Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells

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