TLDR Hair stem cells produce a protein called COL17A1 that plays a key role in their development and is linked to hair thinning and baldness.
The 2019 study demonstrated that hair-follicle-associated pluripotent (HAP) stem cells, which reside in the upper part of the hair follicle, co-express nestin and type-XVII collagen (COL17A1). The expression of HAP stem cell markers (nestin and SSEA1) increased after HAP stem-cell colonies were formed, then decreased after differentiation to epidermal keratinocytes. In contrast, COL17A1 increased after differentiation to epidermal keratinocytes. This suggests that COL17A1 plays a significant role in the differentiation of HAP stem cells. The study also noted that the DNA-damage response in non-HAP hair follicle stem cells induces proteolysis of COL17A1, which is involved in hair-follicle stem-cell maintenance and is associated with hair-follicle miniaturization and androgenic alopecia.
Cited in this study
4 / 4 results
6 citations
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September 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)” Younger mice's hair-follicle stem cells are better at turning into heart cells than older mice's.
29 citations
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March 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)” Isoproterenol helps hair follicle stem cells turn into beating heart muscle cells.
242 citations
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February 2016 in “Science” Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
949 citations
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11 citations
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August 2019 in “Tissue & Cell” Hair stem cells produce a protein called COL17A1 that plays a key role in their development and is linked to hair thinning and baldness.
33 citations
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October 2013 in “PloS one” Human sweat glands have a type of stem cell that can grow well and turn into different cell types.
34 citations
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June 2008 in “In vitro cellular & developmental biology. Animal” Scientists created a long-lasting stem cell line from human hair that can turn into different skin and hair cell types.
1 citations
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January 2008 in “Springer eBooks” Hair follicle stem cells can turn into many cell types and may help repair nerve damage and have other medical uses.
50 citations
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February 2007 in “Expert Opinion on Biological Therapy” Hair follicle stem cells could help repair nerves and avoid ethical issues linked to embryonic stem cells.
