Multipotent Nestin-Positive Stem Cells Reside in the Stroma of Human Eccrine and Apocrine Sweat Glands and Can Be Propagated Robustly In Vitro

    October 2013 in “ PloS one ”
    Sabine Nagel, F. Rohr, Caroline Weber … Anna Emilia Matthießen
    Studysummary This study found that human sweat glands contain unique stem cells with significant multilineage differentiation potential and self-renewal abilities, suggesting promising clinical applications due to easy biopsy access.
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    Research cited in this study 13

    1. Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair Cell · 2012
    2. Human Eccrine Sweat Gland Cells Can Reconstitute a Stratified Epidermis Journal of Investigative Dermatology · 2010
    3. Nestin-Expressing Interfollicular Blood Vessel Network Contributes to Skin Transplant Survival and Wound Healing Journal of Cellular Biochemistry · 2010
    4. Human Hair Follicle Pluripotent Stem Cells Promote Regeneration of Peripheral Nerve Injury: An Advantageous Alternative to ES and iPS Cells Journal of Cellular Biochemistry · 2009
    5. Multipotent Nestin-Expressing Hair Follicle Stem Cells The Journal of Dermatology · 2009
    6. Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    7. The Potential of Nestin-Expressing Hair Follicle Stem Cells in Regenerative Medicine Expert Opinion on Biological Therapy · 2007
    8. Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles American Journal Of Pathology · 2006
    9. Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells Proceedings of the National Academy of Sciences · 2004
    10. Human Follicular Stem Cells: Their Presence in Plucked Hair and Follicular Cell Culture British Journal of Dermatology · 2004
    11. Nestin Expression in Hair Follicle Sheath Progenitor Cells Proceedings of the National Academy of Sciences · 2003
    12. Identification and Dissection of an Enhancer Controlling Epithelial Gene Expression in Skin Proceedings of the National Academy of Sciences · 2001
    13. Changing Patterns of Localization of Putative Stem Cells in Developing Human Hair Follicles Journal of Investigative Dermatology · 2000

    Related research 1

    1. Histochemical and Immunohistochemical Markers for Human Eccrine and Apocrine Sweat Glands: An Aid for Histopathologic Differentiation of Sweat Gland Tumors Journal of Investigative Dermatology Symposium Proceedings · 2001