Identification and Dissection of an Enhancer Controlling Epithelial Gene Expression in Skin

    February 2001 in “ Proceedings of the National Academy of Sciences ”
    Satrajit Sinha, Elaine Fuchs
    Studysummary This study found that the HS III element in the K14 gene's regulatory sequence promotes gene expression in inner root sheath keratinocytes, highlighting cooperative interactions in keratinocyte-specific gene regulation.
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    Research cited in this study 7

    1. The Tissue-Dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1 Journal of Biological Chemistry · 2000
    2. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    3. The Proximal Promoter of the Human Transglutaminase 3 Gene Journal of biological chemistry/˜The œJournal of biological chemistry · 1996
    4. The Epidermis: Rising to the Surface Current opinion in genetics & development · 1994
    5. Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter In Vitro and In Transgenic Mice Molecular and Cellular Biology · 1993
    6. The Secret Life of the Hair Follicle Trends in genetics · 1992
    7. Keratins 1 and 10 as Regular Constituents of Inner Root Sheath and Cuticle Cells in the Human Hair Follicle PubMed · 1990

    Related research 5

    1. Identification and Dissection of an Enhancer Controlling Epithelial Gene Expression in Skin Proceedings of the National Academy of Sciences · 2001
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    3. Overexpression of Human Keratin 16 Produces a Distinct Skin Phenotype in Transgenic Mouse Skin Biochemistry and Cell Biology · 1995
    4. A 5'-Upstream Region of a Bovine Keratin 6 Gene Confers Tissue-Specific Expression and Hyperproliferation-Related Induction in Transgenic Mice Proceedings of the National Academy of Sciences · 1995
    5. Skin-Specific Expression of a Truncated E1a Oncoprotein Binding to p105-Rb Leads to Abnormal Hair Follicle Maturation Without Increased Epidermal Proliferation The Journal of Cell Biology · 1993