The Epidermis: Rising to the Surface

    October 1994 in “ Current opinion in genetics & development ”
    Elaine Fuchs, Carolyn Byrne
    TLDR The document concludes that recent research has improved understanding of skin diseases and the balance between cell growth and differentiation in the epidermis.
    The document from 1994 discusses the protective function of the epidermis, highlighting its complex cytoskeletal structure made of keratin filaments. It notes that recent research has shed light on the molecular basis of skin diseases related to keratins, laminins, and collagen. Additionally, the document emphasizes the role of transcription factors such as AP-1, AP-2, retinoic acid receptors, and POU proteins in regulating epidermal genes. Furthermore, it mentions that studies involving transgenic models and gene ablation of TGF-α and TGF-β have provided insights into the epidermis's ability to maintain a balance between cell growth and differentiation.
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