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GlossaryLaminin

protein crucial for cell adhesion and tissue structure

Laminin is a protein found in the extracellular matrix, which is the network of molecules outside cells that provides structural and biochemical support to surrounding cells. It plays a crucial role in tissue architecture, cell adhesion, differentiation, and migration. Laminin is essential for the integrity and function of tissues, including the skin and hair follicles, making it significant in studies related to hair growth and alopecia.

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research The Epidermis: Rising to the Surface

238 citations, October 1994 in “Current opinion in genetics & development”

The document concludes that recent research has improved understanding of skin diseases and the balance between cell growth and differentiation in the epidermis.

research Laminin-511 Is an Epithelial Message Promoting Dermal Papilla Development and Function During Early Hair Morphogenesis

102 citations, August 2008 in “Genes & Development”

Laminin-511 is crucial for early hair growth and maintaining important hair development signals.

research Re-Investigating the Basement Membrane Zone of Psoriatic Epidermal Lesions: Is Laminin-511 a New Player in Psoriasis Pathogenesis?

13 citations, June 2018 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

Laminin-511 may contribute to psoriasis by affecting skin cell growth and survival.

research Alpha-Parvin Is Required for Epidermal Morphogenesis, Hair Follicle Development, and Basal Keratinocyte Polarity

7 citations, March 2020 in “PloS one”

α-parvin is necessary for skin and hair growth and for the correct orientation of skin cells.

research Integrin α3β1 in Hair Bulge Stem Cells Modulates CCN2 Expression and Promotes Skin Tumorigenesis

5 citations, May 2020 in “Life science alliance”

Removing integrin α3β1 from hair stem cells lowers skin tumor growth by affecting CCN2 protein levels.

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