A 5'-Upstream Region of a Bovine Keratin 6 Gene Confers Tissue-Specific Expression and Hyperproliferation-Related Induction in Transgenic Mice

    May 1995 in “ Proceedings of the National Academy of Sciences ”
    Ángel Ramı́rez, Miguel Vidal, Ana Bravo, Fernando Larcher, José L. Jorcano
    TLDR A specific gene region can control targeted and responsive gene expression in mice, useful for skin disorder treatments.
    The study investigated the regulatory sequences of the bovine keratin 6 gene, which is known for its complex expression pattern in hair follicles and various epithelia, and its induction during hyperproliferative conditions. Researchers used transgenic mice to test different fragments of the gene linked to a beta-galactosidase reporter gene. They found that a 9-kbp fragment from the 5' upstream region was capable of driving both tissue-specific and inducible expression of the reporter gene. This discovery suggested potential applications in gene therapy, particularly for targeting epidermal hyperproliferative disorders.
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