Isoproterenol Directs Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Differentiate In Vitro to Cardiac Muscle Cells Which Can Be Induced to Form Beating Heart-Muscle Tissue Sheets

    March 2016 in “ Cell cycle/Cell cycle (Georgetown, Tex. Online) ”
    Aiko Yamazaki, Masateru Yashiro, Sumiyuki Mii … Yasuyuki Amoh
    Studysummary This study observed that isoproterenol directs hair-follicle-associated pluripotent stem cells to differentiate into cardiac muscle cells in large numbers, forming tissue sheets of beating heart muscle cells in culture.
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    Research cited in this study 8

    1. From Hair to Heart: Nestin-Expressing Hair-Follicle-Associated Pluripotent Stem Cells Differentiate to Beating Cardiac Muscle Cells Cell Cycle · 2015
    2. Nestin-Expressing Hair Follicle-Accessible Pluripotent Stem Cells for Nerve and Spinal Cord Repair Cells tissues organs · 2014
    3. Multipotent Hair Follicle Stem Cells Promote Repair of Spinal Cord Injury and Recovery of Walking Function Cell Cycle · 2008
    4. Chemotherapy Targets the Hair Follicle Vascular Network but Not the Stem Cells Journal of Investigative Dermatology · 2006
    5. Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves Proceedings of the National Academy of Sciences · 2005
    6. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005
    7. Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells Proceedings of the National Academy of Sciences · 2004
    8. Nestin Expression in Hair Follicle Sheath Progenitor Cells Proceedings of the National Academy of Sciences · 2003

    Related research 1

    1. Hair Follicle Stem Cell Marker Nestin Expression in Regenerating Hair Follicles of Patients with Alopecia Areata European Journal of Dermatology · 2011