Rat Hair-Follicle-Associated Pluripotent Stem Cells Can Differentiate Into Atrial or Ventricular Cardiomyocytes in Culture Controlled by Specific Supplementation

    January 2024 in “ PloS one ”
    Nanako Takaoka, Michiko Yamane, Ayami Hasegawa … Yasuyuki Amoh
    Studysummary This study found that rat hair-follicle-associated pluripotent stem cells can be successfully differentiated into beating atrial and ventricular cardiomyocytes by using specific combinations of growth factors and inhibitors in culture, demonstrating their potential to form functional myocardial fibers similar to adult heart cells.
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    Research cited in this study 7

    1. Isoproterenol Directs Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Differentiate In Vitro to Cardiac Muscle Cells Which Can Be Induced to Form Beating Heart-Muscle Tissue Sheets Cell cycle/Cell cycle (Georgetown, Tex. Online) · 2016
    2. From Hair to Heart: Nestin-Expressing Hair-Follicle-Associated Pluripotent Stem Cells Differentiate to Beating Cardiac Muscle Cells Cell Cycle · 2015
    3. Multipotent Hair Follicle Stem Cells Promote Repair of Spinal Cord Injury and Recovery of Walking Function Cell Cycle · 2008
    4. Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves Proceedings of the National Academy of Sciences · 2005
    5. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005
    6. Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells Proceedings of the National Academy of Sciences · 2004
    7. Nestin Expression in Hair Follicle Sheath Progenitor Cells Proceedings of the National Academy of Sciences · 2003

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