Rat Hair-Follicle-Associated Pluripotent Stem Cells Can Differentiate Into Atrial or Ventricular Cardiomyocytes in Culture Controlled by Specific Supplementation

    January 2024 in “ PloS one ”
    Nanako Takaoka, Michiko Yamane, Ayami Hasegawa, Koya Obara, Kyoumi Shirai, Ryoichi Aki, Hiroyasu Hatakeyama, Yuko Hamada, Nobuko Arakawa, Manabu Tanaka, Robert M. Hoffman, Yasuyuki Amoh
    Image of study
    TLDR Rat hair-follicle stem cells can become heart cells with specific supplements.
    In this study, rat hair-follicle-associated pluripotent (HAP) stem cells were successfully differentiated into beating atrial and ventricular cardiomyocytes using specific culture supplements. Atrial cardiomyocytes were induced with isoproterenol, activin A, BMP4, bFGF, and CSA, while ventricular cardiomyocytes were induced with activin A, BMP4, bFGF, IWP4, and VEGF. The differentiated cells were confirmed by specific staining and qPCR, showing significant expression of MLC2a in atrial and MLC2v in ventricular cardiomyocytes. Both cell types exhibited characteristic Ca2+ waveforms and formed functional myocardial fibers, demonstrating the potential of HAP stem cells to generate specific cardiomyocyte subtypes.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  138 upvotes 9 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community Please explain this Minoxidil phenomena

      in Minoxidil  60 upvotes 1 year ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

      community 22 yr asian male 2 year fin results

      in Progress Pictures  135 upvotes 1 year ago
      The user "Top_Replacement_7777" shared their positive results with finasteride for hair loss. They asked about maintaining their hair with finasteride and the impact of vaping on hair growth. Another user reassured them that vaping wouldn't affect their progress.

      community Male pattern baldness, and mental health

      in Finasteride/Dutasteride  330 upvotes 9 months ago
      A 48-year-old man has been using minoxidil for 15 years and considered finasteride but stopped due to potential side effects. He is concerned about his mental health and the impact of hair loss on self-image, and he encourages support among men experiencing hair loss.

    Similar Research

    5 / 1000+ results