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    Glossary Bone Morphogenetic Protein 4

    regulates hair follicle growth and tissue development

    Bone Morphogenetic Protein 4 (BMP4) is a protein that plays a crucial role in the development and growth of various tissues, including bone and hair follicles. It is part of the transforming growth factor-beta (TGF-β) superfamily and is involved in cellular processes such as differentiation, proliferation, and apoptosis. In the context of hair, BMP4 helps regulate the growth cycle of hair follicles and can influence conditions like alopecia.

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    1. Bone morphogenetic proteins 4 and 2/7 induce osteogenic differentiation of mouse skin derived fibroblast and dermal papilla cells Cell and Tissue Research · 2013 · 28 citations
    2. Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway Proceedings of the National Academy of Sciences · 2004 · 70 citations
    3. BONE MORPHOGENETIC PROTEINS ARE CRITICAL FACTORS FOR HAIR FOLLICLE EPITHELIAL –MESENCHYMAL INTERACTIONS IN ANDROGENETIC ALOPECIA 2017
    4. Effect of tofacitinib on the expression of noggin/BMP-4 and hair growth stimulation in mice Archives of Dermatological Research · 2018 · 2 citations
    5. Ectodermal Organ Stem Cells: Morphogenesis, Population Regenerative Behavior, and Evo-Devo 2013 · 1 citations
    6. Ceramide Synthase 4 Regulates Stem Cell Homeostasis and Hair Follicle Cycling Journal of Investigative Dermatology · 2015 · 53 citations
    7. Molecular biology of hair morphogenesis: Development and cycling Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution · 2003 · 155 citations
    8. De novo follicular regeneration of the skin by wingless int 3 and bone morphogenetic protein 2 genes introduced into dermal fibroblasts and fibroblast growth factor‐2 protein Wound Repair and Regeneration · 2009 · 4 citations
    9. 447 Skin-Associated Cartilage Consists of Lipid-Filled Cells That Modify Hair Growth via BMP and WNT Signaling Journal of Investigative Dermatology · 2025
    10. Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface ˜The œAmerican journal of pathology · 2008 · 41 citations
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