Nestin-Expressing Hair Follicle-Accessible Pluripotent Stem Cells for Nerve and Spinal Cord Repair

This study suggests that nestin-expressing hair follicle stem cells, when transplanted into transgenic mice with sciatic nerve injury, can differentiate into motor neurons and reduce muscle atrophy.

This study suggests that skin-derived precursors from Sox2(+) hair follicle dermal cells have the potential to function as dermal stem cells, supporting hair morphogenesis, dermal maintenance, and wound-healing.

In this study, human hair follicle pluripotent stem cells transplanted into severed mouse sciatic nerves differentiated into Schwann cells and supported nerve regeneration, offering a promising alternative to embryonic or iPS cells for regenerative medicine.

This study found that in mice, transplanting hair follicle stem cells promoted recovery from spinal cord injury, as these cells largely differentiated into Schwann cells aiding nerve repair.

This study found that nestin-expressing cells in the hair follicle bulge exhibit multipotent stem cell-like properties and can generate neural cells both in vitro and in vivo.

Human hair follicles can provide stem cells for regenerative medicine.

This study suggests that hair follicle stem cells from transgenic mice can improve nerve regeneration and function, highlighting their potential as an autologous source for regenerative medicine.

This study demonstrated that ND-GFP stem cells from the hair-follicle bulge area can differentiate into various cell types, including neurons, suggesting their potential as a source for therapeutic applications.

This study found that nestin-driven GFP labels blood vessels originating from hair follicles in mice, which could be used to study early events in skin angiogenesis and for antiangiogenesis drug screening.

In this study, nestin-expressing cells in the hair follicle bulge, marked by GFP in transgenic mice, were identified as progenitors of the hair follicle outer-root sheath.

This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.

This article describes the potential role of various growth factors and molecules in regulating mammalian hair follicle development but does not present new experimental results.

This study describes a gel-supported in vitro system for culturing skin samples that may effectively replace animal systems for toxicity testing, showing high correlation with in vivo skin toxicity measurements.