Nestin-Expressing Stem Cells from the Hair Follicle Can Differentiate into Motor Neurons and Reduce Muscle Atrophy After Transplantation to Injured Nerves

    September 2013 in “ Tissue engineering. Part A ”
    Fang Liu, Chuansen Zhang, Robert M. Hoffman
    Studysummary This study suggests that nestin-expressing hair follicle stem cells, when transplanted into transgenic mice with sciatic nerve injury, can differentiate into motor neurons and reduce muscle atrophy.
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    Research cited in this study 12

    1. Multipotent Nestin-Expressing Stem Cells Capable of Forming Neurons Are Located in the Upper, Middle, and Lower Part of the Vibrissa Hair Follicle Cell Cycle · 2012
    2. Embryonic Development of Hair Follicle Pluripotent Stem Cells Medical Molecular Morphology · 2010
    3. Human Hair Follicle Pluripotent Stem Cells Promote Regeneration of Peripheral Nerve Injury: An Advantageous Alternative to ES and iPS Cells Journal of Cellular Biochemistry · 2009
    4. Hair Follicle Pluripotent Stem Cells Human cell culture · 2009
    5. Multipotent Nestin-Expressing Hair Follicle Stem Cells The Journal of Dermatology · 2009
    6. Multipotent Hair Follicle Stem Cells Promote Repair of Spinal Cord Injury and Recovery of Walking Function Cell Cycle · 2008
    7. The Hair Follicle Stem Cell As The Paradigm Multipotent Adult Stem Cell Springer eBooks · 2008
    8. The Potential of Nestin-Expressing Hair Follicle Stem Cells in Regenerative Medicine Expert Opinion on Biological Therapy · 2007
    9. Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves Proceedings of the National Academy of Sciences · 2005
    10. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005
    11. Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells Proceedings of the National Academy of Sciences · 2004
    12. Nestin Expression in Hair Follicle Sheath Progenitor Cells Proceedings of the National Academy of Sciences · 2003