Introduction to Hair-Follicle-Associated Pluripotent Stem Cells

    January 2016 in “ Methods in molecular biology ”
    Robert M. Hoffman
    TLDR HAP stem cells can repair nerves, grow hair follicle nerves, and become heart muscle cells, making them useful for regenerative medicine.
    The document discussed the discovery and potential of nestin-expressing hair-follicle-associated pluripotent (HAP) stem cells, which could form various cell types, including neurons and glial cells, and aid in the repair of peripheral nerve and spinal cord injuries. HAP stem cells were shown to grow and extend hair follicle nerves in 3D histoculture, suggesting their role in sensory nerve growth. Additionally, these cells could differentiate into cardiac muscle cells, offering advantages for regenerative medicine over embryonic and induced pluripotent stem cells due to their accessibility, autologous nature, non-tumorigenicity, and lack of ethical issues.
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