Hair Follicle Associated Pluripotent Stem Cells Stimulate Hair Growth in Transplanted Mice

    December 2022 in “ Scientific Reports ”
    Koya Obara, Jose Reynoso, Yuko Hamada … Robert M. Hoffman
    Studysummary This study found that transplanted hair follicle-associated pluripotent stem cells in mice differentiated into keratinocytes and stimulated hair growth by producing mature hair shafts.
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    Research cited in this study 18

    1. Recreation of a Hair Follicle Regenerative Microenvironment: Successes and Pitfalls Bioengineering & translational medicine · 2021
    2. Rescuing Key Native Traits in Cultured Dermal Papilla Cells for Human Hair Regeneration Journal of Advanced Research · 2020
    3. Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study Journal of The American Academy of Dermatology · 2020
    4. Wnt Activator CHIR99021-Stimulated Human Dermal Papilla Spheroids Contribute to Hair Follicle Formation and Production of Reconstituted Follicle-Enriched Human Skin Biochemical and Biophysical Research Communications · 2019
    5. Bioengineering a 3D Integumentary Organ System from iPS Cells Using an In Vivo Transplantation Model Science Advances · 2016
    6. Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration ACS Applied Materials & Interfaces · 2016
    7. From Hair to Heart: Nestin-Expressing Hair-Follicle-Associated Pluripotent Stem Cells Differentiate to Beating Cardiac Muscle Cells Cell Cycle · 2015
    8. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    9. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    10. Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration Biomaterials · 2012
    11. Multipotent Nestin-Expressing Stem Cells Capable of Forming Neurons Are Located in the Upper, Middle, and Lower Part of the Vibrissa Hair Follicle Cell Cycle · 2012
    12. Hair Organ Regeneration Via Bioengineered Hair Follicular Unit Transplantation Scientific Reports · 2012
    13. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    14. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005
    15. Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells Proceedings of the National Academy of Sciences · 2004
    16. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003
    17. Nestin Expression in Hair Follicle Sheath Progenitor Cells Proceedings of the National Academy of Sciences · 2003
    18. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001

    Related research 4

    1. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015
    2. Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis PloS one · 2011
    3. Future Directions: The Known and Unknown Roles of Hair-Follicle Stem Cell Types 2010
    4. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003