Extensive Hair Shaft Growth After Mouse Whisker Follicle Isolation, Cryopreservation, and Transplantation in Nude Mice

    December 2015 in “ PloS one ”
    Wenluo Cao, Lingna Li, Benjamin Tran, Satoshi Kajiura, Yasuyuki Amoh, Fang Liu, Robert M. Hoffman
    TLDR Cryopreserved mouse whisker follicles can grow hair when transplanted into nude mice.
    The study demonstrated that mouse whisker follicles could be successfully isolated, cryopreserved using DMSO, and transplanted into nude mice, resulting in extensive hair shaft growth over 8 weeks. This process preserved the pluripotency of hair follicle-associated pluripotent (HAP) stem cells, which maintained their ability to differentiate into various cell types. The findings suggested potential applications for hair follicle cryopreservation and transplantation in hair restoration therapies and regenerative medicine, including nerve and spinal cord repair.
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