Extensive Hair Shaft Growth After Mouse Whisker Follicle Isolation, Cryopreservation, and Transplantation in Nude Mice

The study demonstrated that mouse whisker follicles could be successfully isolated, cryopreserved using DMSO, and transplanted into nude mice, resulting in extensive hair shaft growth over 8 weeks. This process preserved the pluripotency of hair follicle-associated pluripotent (HAP) stem cells, which maintained their ability to differentiate into various cell types. The findings suggested potential applications for hair follicle cryopreservation and transplantation in hair restoration therapies and regenerative medicine, including nerve and spinal cord repair.