Augmenting Peripheral Nerve Regeneration Using Rat Hair Follicle Stem Cells in Rats

    June 2021 in “ Basic and Clinical Neuroscience Journal ”
    Leila Beigom Hejazian, Zeinab Akbarnejad, Fatemeh Moghani Ghoroghi, Banafshe Esmaeilzade, Samira Chaibakhsh
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    TLDR Rat hair follicle stem cells can improve nerve repair and muscle function after injury.
    This study investigated the use of rat hair follicle stem cells (rHFSCs) for regenerating sciatic nerve injuries in rats. The research demonstrated that rHFSCs are suitable for cell culture, proliferation, and differentiation. Rats were divided into three groups, and rHFSCs were injected into the site of nerve injury. After 8 weeks, assessments showed that the group receiving rHFSCs with epineurium had more effective nerve repair compared to other groups (P<0.05). The study concluded that rHFSCs improved axonal growth and functional recovery, suggesting their potential in enhancing nerve regeneration and muscle function after peripheral nerve injury. This research highlighted the promise of hair follicle stem cells as a source for stem cell therapy in nerve repair.
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      in Microneedling  18 upvotes 1 year ago
      Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.

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