In Vitro Neural Differentiation of CD34+ Stem Cell Populations in Hair Follicles by Three Different Neural Induction Protocols

October 2014 in “ In vitro cellular & developmental biology. Animal ”

Nowruz Najafzadeh, Mohsen Sagha, Shirin Heydari Tajaddod, Mohammad Ghasem Golmohammadi, Nasim Massahi Oskoui, Maryam Deldadeh Moghaddam

CD34+ stem cells hair follicles neural differentiation neural induction protocols in vitro

TLDR Hair follicle stem cells can become neural cells using different methods, with varying efficiency.

The study compared three different neural induction protocols to differentiate CD34+ stem cell populations from hair follicles into neural cells in vitro. All three protocols were effective, but they varied in efficiency and characteristics of the neural differentiation process. This research highlighted the potential of hair follicle-derived CD34+ stem cells in neural regeneration and provided insights into optimizing neural induction methods for therapeutic applications.

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Research cited in this study

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research Multipotent Nestin-Expressing Hair Follicle Stem Cells

37 citations, January 2009 in “The Journal of Dermatology”

Hair follicle stem cells can turn into various cell types and help repair nerves.

research Neural Potential of a Stem Cell Population in the Hair Follicle

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Stem cells in hair follicles can become various cell types, including neurons.

research The Potential of Nestin-Expressing Hair Follicle Stem Cells in Regenerative Medicine

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Hair follicle stem cells could help repair nerves and avoid ethical issues linked to embryonic stem cells.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

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research Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells

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Hair follicle cells can create new blood vessels in the skin.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations, January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

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