MiR-339-5p Negatively Regulates Loureirin A-Induced Hair Follicle Stem Cell Differentiation by Targeting DLX5

May 2018 in “ Molecular Medicine Reports ”

Xiangjun Li, Yuqiong Wu, Fangfang Xie, Fengxue Zhang, Saixia Zhang, Jianhong Zhou, Dongfeng Chen, Aijun Liu

miR-339-5p loureirin A hair follicle stem cells DLX5 Wnt/β-catenin signaling pathway K10 involucrin Wnt signaling pathway

Studysummary This study found that miR-339-5p negatively regulates loureirin A-induced differentiation of hair follicle stem cells, potentially impacting skin repair and regeneration by inhibiting the Wnt/β-catenin signaling pathway.

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The study explored the role of miR-339-5p in the differentiation of hair follicle stem cells (HFSCs) induced by loureirin A, revealing that miR-339-5p acted as a negative regulator by targeting the DLX5 gene. Downregulation of miR-339-5p increased DLX5 expression and promoted HFSC differentiation, implicating the Wnt/β-catenin signaling pathway in this process. These findings suggested that miR-339-5p and DLX5 could be potential therapeutic targets for skin repair and regeneration, offering insights into molecular mechanisms that could impact hair growth and regeneration.

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