MiR-339-5p Negatively Regulates Loureirin A-Induced Hair Follicle Stem Cell Differentiation by Targeting DLX5

    May 2018 in “ Molecular Medicine Reports ”
    Xiangjun Li, Yuqiong Wu, Fangfang Xie, Fengxue Zhang, Saixia Zhang, Jianhong Zhou, Dongfeng Chen, Aijun Liu
    TLDR miR‑339‑5p can slow down hair follicle stem cell differentiation by targeting DLX5.
    The study explored the role of miR-339-5p in the differentiation of hair follicle stem cells (HFSCs) induced by loureirin A, revealing that miR-339-5p acted as a negative regulator by targeting the DLX5 gene. Downregulation of miR-339-5p increased DLX5 expression and promoted HFSC differentiation, implicating the Wnt/β-catenin signaling pathway in this process. These findings suggested that miR-339-5p and DLX5 could be potential therapeutic targets for skin repair and regeneration, offering insights into molecular mechanisms that could impact hair growth and regeneration.
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