VEGF165 Induces Differentiation of Hair Follicle Stem Cells Into Endothelial Cells and Plays a Role in In Vivo Angiogenesis

    February 2017 in “ Journal of Cellular and Molecular Medicine ”
    Renfu Quan, Weibin Du, Xuan Zheng … Disheng Yang
    Studysummary In this study, VEGF165 induced hair follicle stem cells to differentiate into vascular endothelial cells, potentially supporting angiogenesis and neovascularization, with the Notch signaling pathway affecting differentiation efficiency.
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    Research cited in this study 19

    1. Isoproterenol Directs Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Differentiate In Vitro to Cardiac Muscle Cells Which Can Be Induced to Form Beating Heart-Muscle Tissue Sheets Cell cycle/Cell cycle (Georgetown, Tex. Online) · 2016
    2. Ovine Hair Follicle Stem Cells Derived From Single Vibrissae Reconstitute Haired Skin International Journal of Molecular Sciences · 2015
    3. From Hair to Heart: Nestin-Expressing Hair-Follicle-Associated Pluripotent Stem Cells Differentiate to Beating Cardiac Muscle Cells Cell Cycle · 2015
    4. Paracrine Crosstalk Between Human Hair Follicle Dermal Papilla Cells and Microvascular Endothelial Cells Experimental Dermatology · 2015
    5. Hair Follicle Stem Cells: In Vitro and In Vivo Neural Differentiation World journal of stem cells · 2015
    6. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    7. Advances in a Rapidly Emerging Field of Hair Follicle Stem Cell Research PubMed · 2014
    8. Differentiation of Human Hair Follicle Stem Cells Into Endothelial Cells Induced by Vascular Endothelial and Basic Fibroblast Growth Factors Molecular Medicine Reports · 2013
    9. Human Hair Follicle Stem Cell Differentiation Into Contractile Smooth Muscle Cells Is Induced by Transforming Growth Factor-β1 and Platelet-Derived Growth Factor BB Molecular Medicine Reports · 2013
    10. Keratinocyte Stem Cells but Not Melanocyte Stem Cells Are the Primary Target for Radiation-Induced Hair Graying Journal of Investigative Dermatology · 2013
    11. Human Hair Follicle Pluripotent Stem Cells Promote Regeneration of Peripheral Nerve Injury: An Advantageous Alternative to ES and iPS Cells Journal of Cellular Biochemistry · 2009
    12. Dlx3 Is a Crucial Regulator of Hair Follicle Differentiation and Cycling Development · 2008
    13. Multipotent Hair Follicle Stem Cells Promote Repair of Spinal Cord Injury and Recovery of Walking Function Cell Cycle · 2008
    14. P63 Expression Pattern During Rat Epidermis Morphogenesis and the Role of P63 as a Marker for Epidermal Stem Cells Journal of Cutaneous Pathology · 2006
    15. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    16. Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves Proceedings of the National Academy of Sciences · 2005
    17. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005
    18. Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells Proceedings of the National Academy of Sciences · 2004
    19. Nestin Expression in Hair Follicle Sheath Progenitor Cells Proceedings of the National Academy of Sciences · 2003