VEGF165 Induces Differentiation of Hair Follicle Stem Cells Into Endothelial Cells and Plays a Role in In Vivo Angiogenesis

February 2017 in “ Journal of Cellular and Molecular Medicine ”

Renfu Quan, Weibin Du, Xuan Zheng, Shichao Xu, Qiang Li, Xing Ji, Ximei Wu, Rongxue Shao, Disheng Yang

VEGF165 hair follicle stem cells endothelial cells angiogenesis Notch signaling pathway neovascularization

TLDR VEGF165 helps hair follicle stem cells become blood vessel cells, aiding new blood vessel growth.

The study investigated the role of VEGF165 in inducing the differentiation of hair follicle stem cells (HFSCs) into vascular endothelial cells, highlighting its potential in angiogenesis. It was found that VEGF165, a key factor in angiogenesis, could effectively induce HFSCs to differentiate into endothelial cells, with the Notch signaling pathway potentially influencing this differentiation process. Additionally, in vivo experiments demonstrated that HFSCs could enhance angiogenesis by promoting host-derived neovascularization. These findings suggested that HFSCs might serve as a promising cell source for vascular tissue engineering and cell transplantation, particularly in treating ischemic diseases.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

19 / 19 results

Isoproterenol Directs Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Differentiate In Vitro to Cardiac Muscle Cells Which Can Be Induced to Form Beating Heart-Muscle Tissue Sheets

research Isoproterenol Directs Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Differentiate In Vitro to Cardiac Muscle Cells Which Can Be Induced to Form Beating Heart-Muscle Tissue Sheets

29 citations , March 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

Isoproterenol helps hair follicle stem cells turn into beating heart muscle cells.

research Ovine Hair Follicle Stem Cells Derived From Single Vibrissae Reconstitute Haired Skin

18 citations , August 2015 in “International Journal of Molecular Sciences”

Ovine hair follicle stem cells can regenerate haired skin and may improve wool production.

research From Hair to Heart: Nestin-Expressing Hair-Follicle-Associated Pluripotent Stem Cells Differentiate to Beating Cardiac Muscle Cells

64 citations , May 2015 in “Cell Cycle”

Hair follicle stem cells can become heart muscle cells.

research Paracrine Crosstalk Between Human Hair Follicle Dermal Papilla Cells and Microvascular Endothelial Cells

35 citations , February 2015 in “Experimental Dermatology”

Cells from the base of hair follicles help blood vessel cells survive and grow, which is important for healthy hair.

research Hair Follicle Stem Cells: In Vitro and In Vivo Neural Differentiation

25 citations , January 2015 in “World journal of stem cells”

Hair follicle stem cells can become different cell types and may help treat neurodegenerative disorders.

Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations , March 2014 in “BioEssays”

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

research Advances in a Rapidly Emerging Field of Hair Follicle Stem Cell Research

20 citations , March 2014 in “PubMed”

Hair follicle stem cell research has advanced in understanding and using these cells for hair growth and skin repair.

research Differentiation of Human Hair Follicle Stem Cells Into Endothelial Cells Induced by Vascular Endothelial and Basic Fibroblast Growth Factors

24 citations , November 2013 in “Molecular Medicine Reports”

Human hair follicle stem cells can become endothelial cells with certain growth factors, useful for vascular treatments.

research Human Hair Follicle Stem Cell Differentiation Into Contractile Smooth Muscle Cells Is Induced by Transforming Growth Factor-β1 and Platelet-Derived Growth Factor BB

19 citations , September 2013 in “Molecular Medicine Reports”

Human hair follicle stem cells can become smooth muscle cells using specific growth factors.

research Keratinocyte Stem Cells but Not Melanocyte Stem Cells Are the Primary Target for Radiation-Induced Hair Graying

30 citations , April 2013 in “Journal of Investigative Dermatology”

Radiation mainly affects keratinocyte stem cells, not melanocyte stem cells, causing hair to gray.

research Human Hair Follicle Pluripotent Stem Cells Promote Regeneration of Peripheral Nerve Injury: An Advantageous Alternative to ES and iPS Cells

121 citations , June 2009 in “Journal of Cellular Biochemistry”

Human hair follicle stem cells can safely and effectively help nerve regeneration.

research Dlx3 Is a Crucial Regulator of Hair Follicle Differentiation and Cycling

132 citations , August 2008 in “Development”

Dlx3 is essential for hair growth and regeneration.

research Multipotent Hair Follicle Stem Cells Promote Repair of Spinal Cord Injury and Recovery of Walking Function

144 citations , June 2008 in “Cell Cycle”

Hair follicle stem cells can help repair spinal cord injuries and improve walking.

research P63 Expression Pattern During Rat Epidermis Morphogenesis and the Role of P63 as a Marker for Epidermal Stem Cells

16 citations , September 2006 in “Journal of Cutaneous Pathology”

P63 is a marker for epidermal stem cells in rats.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

research Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves

319 citations , November 2005 in “Proceedings of the National Academy of Sciences”

Hair follicle stem cells can help repair damaged nerves.

research Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons

419 citations , March 2005 in “Proceedings of the National Academy of Sciences”

Hair-follicle stem cells can become neurons.

research Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells

212 citations , August 2004 in “Proceedings of the National Academy of Sciences”

Hair follicle cells can create new blood vessels in the skin.

research Nestin Expression in Hair Follicle Sheath Progenitor Cells

352 citations , August 2003 in “Proceedings of the National Academy of Sciences”

Nestin is found in hair follicle progenitor cells, linking them to neural stem cells.

Similar Research

5 / 83 results

Are Hair Follicle Stem Cells Promising Candidates for Wound Healing?