Human Hair Follicle Stem Cell Differentiation Into Contractile Smooth Muscle Cells Is Induced by Transforming Growth Factor-β1 and Platelet-Derived Growth Factor BB

September 2013 in “ Molecular Medicine Reports ”

Zhi Cheng Xu, Qun Zhang, Hong Li

human hair follicle stem cells transforming growth factor-β1 platelet-derived growth factor BB α-smooth muscle actin α-calponin smooth muscle myosin heavy chain collagen matrix hHFSCs TGF-β1 PDGF-BB

TLDR Human hair follicle stem cells can become smooth muscle cells using specific growth factors.

The study demonstrated that human hair follicle stem cells (hHFSCs) could be efficiently differentiated into contractile smooth muscle cells (SMCs) using transforming growth factor-β1 (TGF-β1) and platelet-derived growth factor BB (PDGF-BB). hHFSCs were obtained from scalp tissues of healthy adults and induced to express SMC-related markers such as α-smooth muscle actin, α-calponin, and smooth muscle myosin heavy chain, similar to human umbilical artery SMCs. These differentiated cells also exhibited contractile function when embedded in a collagen matrix. This method provided a high yield of SMCs, suggesting its potential utility in blood vessel engineering and vascular disease research.

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