TLDR Effective PCOS treatments require targeting specific signaling pathways.
The document reviews the complex signaling pathways and therapeutic strategies for polycystic ovary syndrome (PCOS), highlighting the roles of pathways such as PI3K/Akt, TGF-B/Smads, Wnt/ß-catenin, Hippo/YAP, and others in its pathogenesis. It discusses potential treatments, including exosome therapy, gene therapy, traditional Chinese medicine, and compounds like metformin, myo-inositol, and melatonin, which target these pathways to alleviate symptoms like inflammation, insulin resistance, and androgen excess. The review underscores the multifaceted nature of PCOS and the need for targeted treatments based on a deeper understanding of these signaling pathways.
1 citations,
January 2023 in “Metabolites” Changes in gut bacteria can contribute to the development of Polycystic Ovary Syndrome (PCOS), affecting metabolism, immunity, and causing inflammation. Treatments may involve adjusting these factors.
6 citations,
December 2022 in “Frontiers in Pharmacology” Quercetin may help improve symptoms of polycystic ovary syndrome.
19 citations,
March 2022 in “International Journal of Environmental Research and Public Health” Certain brain hormones and chemicals are linked to the development of Polycystic Ovary Syndrome.
223 citations,
September 2018 in “Rheumatology” JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.
883 citations,
August 2016 in “Nature Reviews Disease Primers” Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.
11 citations,
July 2016 in “Endocrinology” Higher Lnk protein levels in ovaries may lead to insulin resistance in women with PCOS.
10 citations,
November 2010 in “Skin therapy letter” Women with PCOS often have acne because of high androgen levels, and the article reviewed how to treat this type of acne.
