Signaling Pathways and Targeted Therapeutic Strategies for Polycystic Ovary Syndrome

The document reviews the complex signaling pathways and therapeutic strategies for polycystic ovary syndrome (PCOS), highlighting the roles of pathways such as PI3K/Akt, TGF-B/Smads, Wnt/ß-catenin, Hippo/YAP, and others in its pathogenesis. It discusses potential treatments, including exosome therapy, gene therapy, traditional Chinese medicine, and compounds like metformin, myo-inositol, and melatonin, which target these pathways to alleviate symptoms like inflammation, insulin resistance, and androgen excess. The review underscores the multifaceted nature of PCOS and the need for targeted treatments based on a deeper understanding of these signaling pathways.