Comprehensive Overview of Polycystic Ovary Syndrome

    August 2016 in “ Nature Reviews Disease Primers ”
    Ricardo Azziz, Enrico Carmina, Zi-Jiang Chen, Andrea Dunaif, Joop S.E. Laven, Richard S. Legro, Daria Lizneva, Barbara Natterson-Horowtiz, Helena Teede, Bulent O. Yildiz
    Image of study
    TLDR Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.
    The document from 2016 provides a comprehensive overview of Polycystic Ovary Syndrome (PCOS), a condition affecting 5-20% of women of reproductive age, characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology. It discusses the associated metabolic dysfunctions such as insulin resistance, the increased risk of type 2 diabetes, gestational diabetes, and cardiovascular events, as well as the psychological impact, including depression and anxiety. The document also explores the genetic factors, with nearly 100 susceptibility genes identified, and the pathophysiological mechanisms, such as increased Anti-Müllerian Hormone (AMH) levels and Luteinizing Hormone (LH) hypersecretion. It emphasizes the importance of screening for metabolic and psychological morbidities, lifestyle interventions as the first-line treatment, and various pharmacological treatments for managing metabolic dysfunction and hyperandrogenism. The document also highlights the need for future research to understand the genotype-phenotype associations, underlying mechanisms, and the development of novel treatments for hirsutism and androgenic alopecia.
    Discuss this study in the Community →

    Research cited in this study

    21 / 21 results

    Related Community Posts Join

    6 / 9 results

      community Proposed new pathogenesis model for androgenetic alopecia (AGA)

      in Research/Science  6 upvotes 2 years ago
      The conversation discusses a new model for understanding androgenetic alopecia (AGA), linking it to dietary and lifestyle factors similar to PCOS, and highlighting the role of DHT, vascular damage, and inflammation. Treatments mentioned include Minoxidil, finasteride, and RU58841.

      community Balding without a family history

      in Chat  7 upvotes 1 day ago
      The user is experiencing hair loss without a family history and suspects stress or telogen effluvium (TE) as the cause, despite using finasteride without results. Others suggest stress, vitamin deficiencies, or other conditions could be factors, and some mention that balding can occur without a family history.

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 1 year ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

      community Dutasteride is amazing even for women with FAGA!

      in Female  151 upvotes 3 months ago
      Dutasteride significantly improved hair health and reduced shedding for a woman with PCOS and hyperandrogenism, without causing depression or anxiety, unlike finasteride. Dutasteride also helped with PMDD symptoms and had no side effects, though it changed hair texture.

    Similar Research

    6 / 1000+ results