The Role of MicroRNA, Long Non-Coding RNA, and Circular RNA in the Pathogenesis of Polycystic Ovary Syndrome: A Literature Review

This literature review examines the roles of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in the pathogenesis of Polycystic Ovary Syndrome (PCOS). It highlights that dysregulated miRNAs contribute to key PCOS complications such as insulin resistance, hyperandrogenism, and hormonal imbalances. Specific miRNAs like miR-93 and miR-21 are linked to insulin resistance and hyperandrogenism, while circRNAs such as circRANBP9 and circPMSC3 are involved in granulosa cell growth and apoptosis. The review suggests that these non-coding RNAs could serve as biomarkers and therapeutic targets, although further research is needed to translate these findings into clinical practice.