Polycystic Ovary Syndrome: Etiology, Pathogenesis, and Diagnosis

    January 2011 in “ Nature Reviews Endocrinology
    Mark O. Goodarzi, Daniel A. Dumesic, Gregorio D. Chazenbalk, Ricardo Azziz
    Image of study
    TLDR The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.
    The document from 2011 reviews the etiology, pathogenesis, and diagnosis of Polycystic Ovary Syndrome (PCOS), a common endocrine disorder affecting up to 10% of women of reproductive age. It is characterized by symptoms such as hyperandrogenism, oligo-ovulation, and polycystic ovarian morphology, often accompanied by insulin resistance. The condition is linked to various morbidities, including infertility, obstetrical complications, type 2 diabetes, cardiovascular disease, and mood disorders. The document suggests that both genetic and environmental factors contribute to PCOS, with a heritability rate of 0.79 among Dutch twins and potential influences from prenatal testosterone exposure and lifestyle factors like weight gain. It also discusses the increased risk of mood disorders, endometrial abnormalities, and the evolutionary context of PCOS. Diagnosis involves confirming symptoms and excluding other conditions, while treatment is tailored to individual needs, focusing on symptom management and prevention of long-term complications. The document is a review and does not provide specific numbers of people studied.
    Discuss this study in the Community →

    Cited in this study

    16 / 16 results