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    Glossary miR-21

    small RNA molecule regulating gene expression and hair follicle development

    miR-21 is a type of microRNA, which are small molecules that help regulate gene expression in cells. It is known to play a role in various biological processes, including cell growth, apoptosis (programmed cell death), and differentiation. In the context of hair and alopecia, miR-21 has been implicated in the regulation of hair follicle development and cycling, and its dysregulation may contribute to hair loss conditions.

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    1. Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling Science Advances · 2020 · 65 citations
    2. Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes Scientific Reports · 2017 · 54 citations
    3. miR‐218‐5p regulates skin and hair follicle development through Wnt/β‐catenin signaling pathway by targeting SFRP2 Journal of cellular physiology · 2019 · 54 citations
    4. A lipid–polymer hybrid nanoparticle (LPN)-loaded dissolving microneedle patch for promoting hair regrowth by transdermal miR-218 delivery Biomaterials Science · 2022 · 13 citations
    5. Melatonin regulates the mitogen-activated protein kinase ( MAPK ) pathway via the circMPP5-miR-211-MAPK3 axis to induce secondary hair follicle differentiation and development in newborn Cashmere goat kids Research Square (Research Square) · 2022 · 1 citations
    6. Experimental dataset for: Hair follicle neural crest stem cell-derived exosomes promote peripheral nerve regeneration via miR-214-3p Mendeley Data · 2026
    7. Mesenchymal stem cell-derived exosomes promote scalp rejuvenation through type XVII collagen regulation via the miR-21-5p/DKK2/Wnt pathway Frontiers in Cell and Developmental Biology · 2026
    8. Experimental dataset for: Hair follicle neural crest stem cell-derived exosomes promote peripheral nerve regeneration via miR-214-3p Mendeley Data · 2026
    9. Low-frequency electromagnetic fields ameliorate testosterone-induced androgenetic alopecia in mice through LncRNA H19/miR-214-5p/β-catenin signal pathway Regenerative Therapy · 2026
    10. The Role of miR-214-3p in Hair Follicle Neural Crest Stem Cell-derived Exosomes in the Repair of Peripheral Nerve Injury 2025
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