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    Glossary miR-21

    small RNA molecule regulating gene expression and hair follicle development

    miR-21 is a type of microRNA, which are small molecules that help regulate gene expression in cells. It is known to play a role in various biological processes, including cell growth, apoptosis (programmed cell death), and differentiation. In the context of hair and alopecia, miR-21 has been implicated in the regulation of hair follicle development and cycling, and its dysregulation may contribute to hair loss conditions.

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    1. Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling Science Advances · 2020 · 65 citations
    2. Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes Scientific Reports · 2017 · 54 citations
    3. miR‐218‐5p regulates skin and hair follicle development through Wnt/β‐catenin signaling pathway by targeting SFRP2 Journal of cellular physiology · 2019 · 54 citations
    4. A lipid–polymer hybrid nanoparticle (LPN)-loaded dissolving microneedle patch for promoting hair regrowth by transdermal miR-218 delivery Biomaterials Science · 2022 · 13 citations
    5. Melatonin regulates the mitogen-activated protein kinase ( MAPK ) pathway via the circMPP5-miR-211-MAPK3 axis to induce secondary hair follicle differentiation and development in newborn Cashmere goat kids Research Square (Research Square) · 2022 · 1 citations
    6. Experimental dataset for: Hair follicle neural crest stem cell-derived exosomes promote peripheral nerve regeneration via miR-214-3p Mendeley Data · 2026
    7. Mesenchymal stem cell-derived exosomes promote scalp rejuvenation through type XVII collagen regulation via the miR-21-5p/DKK2/Wnt pathway Frontiers in Cell and Developmental Biology · 2026
    8. Experimental dataset for: Hair follicle neural crest stem cell-derived exosomes promote peripheral nerve regeneration via miR-214-3p Mendeley Data · 2026
    9. Low-frequency electromagnetic fields ameliorate testosterone-induced androgenetic alopecia in mice through LncRNA H19/miR-214-5p/β-catenin signal pathway Regenerative Therapy · 2026
    10. The Role of miR-214-3p in Hair Follicle Neural Crest Stem Cell-derived Exosomes in the Repair of Peripheral Nerve Injury 2025
    11. The Role of miR-214-3p in Hair Follicle Neural Crest Stem Cell-derived Exosomes in the Repair of Peripheral Nerve Injury 2025
    12. Comprehensive Transcriptome Analysis of Hair Follicle Morphogenesis Reveals That lncRNA-H19 Promotes Dermal Papilla Cell Proliferation through the Chi-miR-214-3p/β-Catenin Axis in Cashmere Goats International journal of molecular sciences · 2022 · 7 citations
    13. MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway Journal of Cell Biology · 2014 · 103 citations
    14. MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment Molecular diagnosis & therapy · 2017 · 32 citations
    15. Interplay of MicroRNA-21 and SATB1 in Epidermal Keratinocytes during Skin Aging Journal of Investigative Dermatology · 2019 · 16 citations
    16. DNMT1-mediated methylation inhibits microRNA-214-3p and promotes hair follicle stem cell differentiate into adipogenic lineages Stem cell research & therapy · 2020 · 8 citations
    17. Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells Frontiers in Genetics · 2022 · 3 citations
    18. Exosomal miRNA-218–5p derived from low-passage dermal papilla cells modulates hair follicle growth and development Non-coding RNA Research · 2026
    19. The Enticing Path of miR Therapeutics: Difficult but Not without Prospects Cells · 2022
    20. MiR-23b and miR-133 Cotarget TGFβ2/NOTCH1 in Sheep Dermal Fibroblasts, Affecting Hair Follicle Development Cells · 2024 · 4 citations
    21. miR-129-5p Participates in Hair Follicle Growth by Targeting HOXC13 in Rabbit Genes · 2022 · 5 citations
    22. Human Amniotic Fluid Stem Cell-Derived Exosomes as a Novel Cell-Free Therapy for Cutaneous Regeneration Frontiers in Cell and Developmental Biology · 2021 · 74 citations
    23. MicroRNA in skin diseases European Journal of Dermatology · 2017 · 27 citations
    24. Lysophosphatidic acid increases the proliferation and migration of adipose-derived stem cells via the generation of reactive oxygen species Molecular Medicine Reports · 2015 · 24 citations
    25. Activation and regulation of the granulation tissue derived cells with stemness-related properties Stem Cell Research & Therapy · 2015 · 14 citations
    26. Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation Cells · 2022 · 12 citations
    27. Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets Experimental Dermatology · 2022 · 3 citations
    28. Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats Frontiers in Veterinary Science · 2025 · 2 citations
    29. The Role of MicroRNA, Long Non-Coding RNA and Circular RNA in the Pathogenesis of Polycystic Ovary Syndrome: A Literature Review International journal of molecular sciences · 2024 · 1 citations
    30. Melatonin promotes the development of the secondary hair follicles by regulating circMPP5 Journal of Animal Science and Biotechnology · 2023 · 1 citations