TLDR MicroRNA-21 could help diagnose and treat skin fibrosis.
The document reviewed the role of microRNA-21 (miR-21) in skin fibrosis, highlighting its potential for diagnosis and treatment. It discussed how miR-21 was implicated in various fibrotic conditions, including keloids and systemic sclerosis, by promoting collagen production and fibroblast proliferation. Studies indicated that miR-21 could be a therapeutic target, as its inhibition induced apoptosis in dermal fibroblasts of systemic sclerosis patients. The document also noted the regulatory mechanisms of miR-21, such as its interaction with Smad7 and the feedback loop involving PDCD4 and AP-1, which contributed to fibrosis development.
27 citations
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October 2013 in “Experimental dermatology” Scleroderma patients have lower hair miR-29a levels.
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July 2013 in “Journal of dermatological science” Hair microRNAs could be effective biomarkers for diagnosing scleroderma.
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July 2017 in “Clinical Science” MicroRNAs are important for skin health and could be targets for new skin disorder treatments.
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June 2023 in “Cells” Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.
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February 2021 in “Pharmacological research” Exosomes can improve skin health and offer new treatments for skin repair and rejuvenation.
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June 2018 in “Journal of The American Academy of Dermatology” Genes linked to fibrosis are more active in people with central centrifugal cicatricial alopecia.
