TLDR MicroRNA-21 could help diagnose and treat skin fibrosis.
The document reviewed the role of microRNA-21 (miR-21) in skin fibrosis, highlighting its potential for diagnosis and treatment. It discussed how miR-21 was implicated in various fibrotic conditions, including keloids and systemic sclerosis, by promoting collagen production and fibroblast proliferation. Studies indicated that miR-21 could be a therapeutic target, as its inhibition induced apoptosis in dermal fibroblasts of systemic sclerosis patients. The document also noted the regulatory mechanisms of miR-21, such as its interaction with Smad7 and the feedback loop involving PDCD4 and AP-1, which contributed to fibrosis development.
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