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    Glossary SMAD7

    inhibits TGF-β signaling to regulate cell growth and differentiation

    SMAD7, also known as Mothers against decapentaplegic homolog 7, is a protein that plays a crucial role in regulating cellular processes by inhibiting the TGF-β (Transforming Growth Factor-beta) signaling pathway. This pathway is involved in cell growth, differentiation, and apoptosis. By acting as an antagonist, SMAD7 helps to control and fine-tune these cellular responses, which can be important in contexts such as tissue repair, immune response, and even cancer development.

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    1. Smad7-Induced β-Catenin Degradation Alters Epidermal Appendage Development Developmental Cell · 2006 · 147 citations
    2. Human bone marrow mesenchymal stem cell-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway Stem Cell Research & Therapy · 2020 · 139 citations
    3. Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues The EMBO Journal · 2002 · 111 citations
    4. Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes Nucleic Acids Research · 2002 · 79 citations
    5. Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity Developmental Biology · 2008 · 28 citations
    6. Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes Plastic and Reconstructive Surgery · 2007 · 16 citations
    7. miR-370-3p Inhibited the Proliferation of Sheep Dermal Papilla Cells by Inhibiting the Expression of SMAD4 Cells · 2025 · 4 citations
    8. Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation Cell Death Discovery · 2022 · 1 citations
    9. Human bone marrow mesenchymal stem cells-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway Research Square (Research Square) · 2020 · 1 citations
    10. Exploring the Complexities of TGF-beta Signaling in Keloids: Beyond the Classical Smad Pathway International Journal of Molecular Sciences · 2026
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