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GlossarySMAD7

inhibits TGF-β signaling to regulate cell growth and differentiation

SMAD7, also known as Mothers against decapentaplegic homolog 7, is a protein that plays a crucial role in regulating cellular processes by inhibiting the TGF-β (Transforming Growth Factor-beta) signaling pathway. This pathway is involved in cell growth, differentiation, and apoptosis. By acting as an antagonist, SMAD7 helps to control and fine-tune these cellular responses, which can be important in contexts such as tissue repair, immune response, and even cancer development.

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research Smad7-Induced Beta-Catenin Degradation Alters Epidermal Appendage Development

147 citations , September 2006 in “Developmental Cell”

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

research Overexpression of Smad7 Results in Severe Pathological Alterations in Multiple Epithelial Tissues

111 citations , June 2002 in “The EMBO Journal”

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

research Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway

139 citations , May 2020 in “Stem Cell Research & Therapy”

Exosomes from stem cells help wounds heal faster by affecting specific cell signals.

Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

research Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

54 citations , November 2017 in “Scientific Reports”

The study found that certain microRNAs are higher in the cells and lower in the fluid of women with a specific type of polycystic ovary syndrome, and one microRNA could potentially help diagnose the condition.

research MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment

32 citations , July 2017 in “Molecular diagnosis & therapy”

MicroRNA-21 could help diagnose and treat skin fibrosis.

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community My Theory Of Androgenic Alopecia

in Research/Science 17 upvotes 2 weeks ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community 30 M diffuse shining/bolding crown - stack

in Treatment 2 upvotes 1 year ago

A 30-year-old with diffuse thinning and a balding crown is using a treatment regimen of a 2-in-1 pill containing finasteride, minoxidil, and biotin, along with various supplements. After two weeks, no side effects have been experienced, and updates with pictures will be posted monthly.

community What's your option on complementary treatment

in Product 3 upvotes 1 year ago

The conversation discusses complementary treatments for hair loss while using finasteride and minoxidil, including scalp massagers, scrubs, coconut oil, and vitamin supplements. The user seeks opinions on these additional treatments.

community Creatine's effect on Hair Loss and DHT

in Research/Science 100 upvotes 1 year ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

community Creatine Does Not Increase DHT And Does Not Cause Hair Loss - Randomized Controlled Trial

in Research/Science 307 upvotes 7 months ago

Creatine does not increase DHT levels or cause hair loss. Personal experiences vary, but scientific evidence shows no link between creatine and hair loss.