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GlossarySMAD signaling

cellular process transmitting signals from surface to nucleus

SMAD signaling, also known as the SMAD pathway, is a cellular process that transmits signals from the cell surface to the nucleus in response to transforming growth factor-beta (TGF-β) and related cytokines. This pathway involves SMAD proteins, which are activated by receptor kinases and then move into the nucleus to regulate gene expression. This signaling is crucial for various biological processes, including cell growth, differentiation, and development, and has implications in conditions like cancer and fibrosis.

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research From Hair to Liver: Emerging Application of Hair Follicle Mesenchymal Stem Cell Transplantation Reverses Liver Cirrhosis by Blocking the TGF-β/Smad Signaling Pathway to Inhibit Pathological HSC Activation

4 citations, February 2022 in “PeerJ”

Hair follicle stem cell transplants can reverse liver cirrhosis by blocking harmful cell activation.

research A Novel Small Compound HPH-15 Antagonizes TGF-β/Smad Signaling and Ameliorates Experimental Skin Fibrosis

April 2017 in “Journal of Investigative Dermatology”

HPH-15, a new compound, effectively reduces skin fibrosis in experiments without causing harm.

research HtrA1L364P Leads to Cognitive Dysfunction and Vascular Destruction Through TGF-β/Smad Signaling Pathway in CARASIL Model Mice

3 citations, July 2022 in “Brain and Behavior”

The HtrA1L364P mutation causes brain dysfunction and blood vessel damage.

research Data from Elevated Cutaneous Smad Activation Associates with Enhanced Skin Tumor Susceptibility in Organ Transplant Recipients

March 2023

Higher TGF-β signaling may increase skin cancer risk in organ transplant recipients.

research Transforming Growth Factor-β, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

16 citations, February 2007 in “Plastic and Reconstructive Surgery”

Keratinocytes show more TGF-β system activity and collagen production as they age, which might affect wound scarring.

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community Creatine's effect on Hair Loss and DHT

in Research/Science 100 upvotes 8 months ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

community Minox and fin since start of January 2020, also shaved my head twice since then to get full effects of the minoxidil and reach the whole scalp easier, that’s honestly a huge key

in Progress Pictures 235 upvotes 3 years ago

User experienced significant hair regrowth using Minoxidil and Finasteride since January 2020, with no side effects reported. Shaving head twice helped Minoxidil reach scalp more effectively.

community Progress – 24.03.21 – 29.06.22 Finasteride 1mg a day

in Progress Pictures 1075 upvotes 2 years ago

A user's progress with treating hair loss using 1mg finasteride per day, with reports of no noticeable side effects and positive results. Other users have shared their experiences with different treatments, such as Dutasteride and Minoxidil.

community 2.5 months topical minoxidil Progress

in Progress Pictures 434 upvotes 9 months ago

The conversation is about a user's hair regrowth after 2.5 months using topical minoxidil. Some suggest adding finasteride for long-term results, while others share their experiences with side effects or alternative treatments like dermarolling and dietary improvements.

community Finasteride only reduces scalp DHT by ~40%. Why does it work?

in Finasteride/Dutasteride 37 upvotes 1 year ago

How Finasteride and Dutasteride help reduce hair loss by reducing the amount of DHT in scalp areas, as well as discussing factors such as sensitivity to DHT, 5α-reductase expression in different parts of the hair follicle, and scalp tension.

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