Polysulfonic Acid Mucopolysaccharide Exerts Anti-Scarring Effect in Rats Through Modulation of TGF-β1/Smad Signaling Pathway

February 2023 in “ Tropical Journal of Pharmaceutical Research ”

Xiaowei Sha, Gang Liu, Siyu Wang, Yujie Mao, Jun Xie

polysulfonic acid mucopolysaccharide TGF-β1 Smad signaling pathway collagen type I collagen type III α-SMA

TLDR Polysulfonic acid mucopolysaccharide can reduce skin scarring.

The study investigated the anti-scarring effects of polysulfonic acid mucopolysaccharide (MSP) in 60 male Sprague Dawley rats, divided into control, model, and MSP groups. The results showed that MSP significantly improved skin tissue thickness and reduced inflammatory infiltration compared to the model group. Additionally, MSP-fed rats exhibited down-regulation of collagen types I and III and α-SMA, indicating a modulation of the TGF-β1/Smad signaling pathway. The findings suggest that MSP has potential clinical applications for minimizing skin scarring.

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