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GlossarySMAD signaling

cellular process transmitting signals from surface to nucleus

SMAD signaling, also known as the SMAD pathway, is a cellular process that transmits signals from the cell surface to the nucleus in response to transforming growth factor-beta (TGF-β) and related cytokines. This pathway involves SMAD proteins, which are activated by receptor kinases and then move into the nucleus to regulate gene expression. This signaling is crucial for various biological processes, including cell growth, differentiation, and development, and has implications in conditions like cancer and fibrosis.

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research From Hair to Liver: Emerging Application of Hair Follicle Mesenchymal Stem Cell Transplantation Reverses Liver Cirrhosis by Blocking the TGF-β/Smad Signaling Pathway to Inhibit Pathological HSC Activation

4 citations , February 2022 in “PeerJ”

Hair follicle stem cell transplants can reverse liver cirrhosis by blocking harmful cell activation.

research HtrA1L364P Leads to Cognitive Dysfunction and Vascular Destruction Through TGF-β/Smad Signaling Pathway in CARASIL Model Mice

3 citations , July 2022 in “Brain and Behavior”

The HtrA1L364P mutation causes brain dysfunction and blood vessel damage.

research Polysulfonic Acid Mucopolysaccharide Exerts Anti-Scarring Effect in Rats Through Modulation of TGF-β1/Smad Signaling Pathway

1 citations , February 2023 in “Tropical Journal of Pharmaceutical Research”

Polysulfonic acid mucopolysaccharide can reduce skin scarring.

research Human Bone Marrow Mesenchymal Stem Cells-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway

1 citations , May 2020 in “Research Square (Research Square)”

Exosomes from stem cells help wounds heal faster by affecting specific cell signals.

research Human Bone Marrow Mesenchymal Stem Cells-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway

April 2020 in “Research Square (Research Square)”

Exosomes from stem cells help wounds heal faster by affecting specific cell signals.

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community My Theory Of Androgenic Alopecia

in Research/Science 17 upvotes 1 week ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Creatine's effect on Hair Loss and DHT

in Research/Science 104 upvotes 1 year ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

community Creatine Does Not Increase DHT And Does Not Cause Hair Loss - Randomized Controlled Trial

in Research/Science 307 upvotes 7 months ago

Creatine does not increase DHT levels or cause hair loss. Personal experiences vary, but scientific evidence shows no link between creatine and hair loss.

community Minox and fin since start of January 2020, also shaved my head twice since then to get full effects of the minoxidil and reach the whole scalp easier, that’s honestly a huge key

in Progress Pictures 234 upvotes 4 years ago

User experienced significant hair regrowth using Minoxidil and Finasteride since January 2020, with no side effects reported. Shaving head twice helped Minoxidil reach scalp more effectively.

community Progress – 24.03.21 – 29.06.22 Finasteride 1mg a day

in Progress Pictures 1075 upvotes 3 years ago

A user's progress with treating hair loss using 1mg finasteride per day, with reports of no noticeable side effects and positive results. Other users have shared their experiences with different treatments, such as Dutasteride and Minoxidil.

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