Distinct Transcriptional Profiles of the Female, Male, and Finasteride-Induced Feminized Male Anogenital Region in Rat Fetuses

    February 2019 in “ Toxicological Sciences
    Camilla Schwartz, Anne Marie Vinggaard, Sofie Christiansen, Thomas A Darde, Frédéric Chalmel, Terje Svingen
    Image of study
    TLDR Finasteride exposure affects gene expression and anogenital distance in male rat fetuses.
    The study aimed to understand the molecular mechanisms behind chemically induced shortening of the anogenital distance (AGD) in male rat fetuses, which is a marker for incomplete masculinization and a predictor of adverse effects on male reproductive health. The anti-androgenic drug finasteride was used to induce short AGD, and transcriptomics analysis on anogenital tissues revealed a sexually dimorphic transcriptional profile. The study provides insights into the molecular mechanisms underlying sexual differentiation and the effects of finasteride on the development of male genitalia. The study suggests that exposure to finasteride during fetal development can lead to changes in gene expression and anogenital distance in male rats.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community Temporary alternative to finasteride?

      in Finasteride  50 upvotes 2 days ago
      A 23-year-old male plans to temporarily stop finasteride to donate plasma for financial reasons and seeks alternative hair loss treatments like minoxidil, ketoconazole, or RU58841 during this period. He is open to suggestions to prevent further hair loss until he can resume finasteride.

      community Sensitive liver, topical fin safe to try?

      in Finasteride  98 upvotes 5 days ago
      Topical finasteride is considered safer for the liver than oral finasteride due to less systemic absorption, but regular liver function tests are advised. The user is concerned about liver health due to a history of NAFLD and is exploring topical finasteride as a safer alternative.

      community 8 months Fin + Oral Minox - still losing some hairs, normal?

      in Finasteride  90 upvotes 1 week ago
      After 8 months of using oral Minoxidil 5mg and Finasteride 1mg, the user still experiences hair loss, particularly miniaturized hairs in the mid-scalp area, along with itching. They are concerned about losing around 40 hairs daily despite treatment.

      community Finasteride - discomfort pelvir/urethra

      in Finasteride  79 upvotes 1 week ago
      Finasteride can cause pelvic or urethral discomfort for some users. Reducing the dose to 0.25 mg on Mondays, Wednesdays, and Fridays is being considered as a potential solution.

    Related Research

    2 / 2 results