Human Bone Marrow Mesenchymal Stem Cells-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway

May 2020 in “ Research Square (Research Square) ”

Tiechao Jiang, Zhongyu Wang, Ji Sun

human bone marrow mesenchymal stem cells exosomes cutaneous wound healing TGF-β Smad signaling pathway keratinocytes dermal fibroblasts

TLDR Exosomes from stem cells help wounds heal faster by affecting specific cell signals.

The study investigated the effects of human bone marrow mesenchymal stem cells-derived exosomes (hBM-MSCs-Ex) on cutaneous wound healing in rats. It was found that hBM-MSCs-Ex effectively promoted the growth of human keratinocytes and human dermal fibroblasts, accelerating wound healing. The mechanism involved the modulation of the TGF-β/Smad signaling pathway, with a down-regulation of TGF-β1, Smad2, Smad3, and Smad4, and an up-regulation of TGF-β3 and Smad7. These findings suggested that hBM-MSCs-Ex could be a promising cell-free therapeutic strategy for treating cutaneous wounds.

View this study on researchsquare.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Similar Research

6 / 1000+ results

research MSCs and Their Exosomes: A Rapidly Evolving Approach in the Context of Cutaneous Wound Therapy

25 citations , December 2021 in “Stem Cell Research & Therapy”

MSCs and their exosomes may speed up skin wound healing but need more research for consistent use.

Exosomes and Their Bioengineering Strategies in Cutaneous Wound Healing and Related Complications: Current Knowledge and Future Perspectives

research Exosomes and Their Bioengineering Strategies in Cutaneous Wound Healing and Related Complications: Current Knowledge and Future Perspectives

72 citations , January 2023 in “International Journal of Biological Sciences”

Engineered exosomes show promise for improving wound healing but face challenges in clinical use.

research Exosomes: A Promising Strategy for Repair, Regeneration and Treatment of Skin Disorders

1 citations , June 2023 in “Cells”

Exosomes could be a promising way to help repair skin and treat skin disorders.

research The Role of Exosomes Derived from Mesenchymal Stromal Cells in Dermatology

44 citations , April 2021 in “Frontiers in Cell and Developmental Biology”

MSC-derived exosomes may help in skin repair and regeneration.

research Stem Cell Therapy for Burns: The Story So Far

August 2021

Stem cell therapy shows promise for better burn healing but needs more research and standardization.

research Regenerative Potential and Clinical Application of Mesenchymal Stem Cell-Derived Exosomes

November 2023 in “Klìtinna ta organna transplantologìâ”

MSC-derived exosomes can help treat COVID-19, hair loss, skin aging, and arthritis.

Human Bone Marrow Mesenchymal Stem Cells-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway

Research cited in this study

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

Related Community Posts Join

community Promising Topical Procyanidin B2 Treatment?

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

community Why the cure is not yet found and why it is always 5 years away? Why no hopes on PP405, GT, KX, Hair cloning, AMP, etc, etc, etc

community If we can clone a sheep why we can't cure baldness till now

community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

community This is the best time in human history to be fighting hair loss