Novel Therapeutic Approaches in Utilizing Platelet Lysate in Regenerative Medicine: Are We Ready for Clinical Use?

    March 2019 in “ Journal of cellular physiology ”
    Majid Zamani, Yoda Yaghoubi, Aliakbar Movassaghpour, Seyed Kazem Shakouri, Amir Mehdizadeh, Alireza Pishgahi, Mehdi Yousefi
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    TLDR Platelet lysate is a promising, cost-effective option for regenerative medicine with potential clinical applications.
    The document from March 25, 2019, discusses the potential of platelet lysate (PL) in regenerative medicine, highlighting its advantages such as containing a high concentration of growth factors, being cost-effective, and easy to produce. PL, which is rich in growth factors like platelet-derived growth factor and vascular endothelial growth factor, has been increasingly considered for clinical applications in various fields including wound healing, bone regeneration, alopecia, and more. The paper reviews recent progress in the use of PL for treating diseases and its potential to substitute other hemoderivative materials in cell therapy and tissue transplantation. The authors suggest that PL is a promising alternative to fetal bovine serum for cell culture and has a significant role in cell proliferation, wound healing, and angiogenesis.
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