Alopecia and Platelet-Derived Therapies

    November 2017 in “ Stem cell investigation
    John P. Cole, Megan A Cole, Chiara Insalaco, Valerio Cervelli, Pietro Gentile
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    Studysummary This study found that platelet lysate produced higher follicular regeneration in hair restoration surgeries compared to activated PRP and saline, with significant gains in both follicular unit and hair density.
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    The study examined the effectiveness of platelet lysate (PL) and activated autologous platelet-rich plasma (AA-PRP) in promoting hair growth during hair restoration surgeries for androgenetic alopecia (AGA). It included three male patients who received PL, AA-PRP, or saline in different scalp areas during transplantation, and a fourth patient who received only PL. The results indicated that PL was more effective in follicular regeneration than AA-PRP or saline, with 89% and 99% of follicular units showing hair regrowth at 3.5 and 4 months post-operation in PL-treated areas, respectively. The patient treated exclusively with PL showed a 50% increase in follicular unit density and a 122% increase in hair density at 7 months. PL also had higher levels of growth factors than AA-PRP. The study concluded that PL is a promising treatment for hair loss and could improve the outcomes of hair restoration surgeries. However, the study had a small sample size, with only four patients.
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