Meta-Analysis of Efficacy of Platelet-Rich Plasma Therapy for Androgenetic Alopecia

May 2016 in “ Journal of Dermatological Treatment ”

Anik Gupta, Jessie Carviel

platelet-rich plasma androgenetic alopecia growth factors cell survival proliferation differentiation vascularization angiogenesis PRP AGA

TLDR PRP therapy may effectively treat hair loss, but more research needed.

This document is a meta-analysis of studies on the efficacy of platelet-rich plasma (PRP) therapy for androgenetic alopecia (AGA). The study concludes that PRP may be an effective treatment for AGA, but further research is needed to refine treatment protocols and establish it as an approved therapy. The overall standardized mean difference was 0.51 in favor of PRP treatment when compared to baseline. PRP is a rich source of growth factors that can stimulate cell survival, proliferation, differentiation, vascularization, and angiogenesis.

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Research cited in this study

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PRP injections improve hair thickness for baldness.

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AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.

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research Platelet-Rich Plasma in Androgenic Alopecia: Myth or Effective Tool

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Platelet-rich plasma (PRP) is a cheap and easy treatment for hair loss, but not suitable for everyone. It also helps in healing ulcers, rejuvenating skin, and improving hair transplants.

research Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

164 citations, January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

PRP injections increase hair density and satisfaction in androgenetic alopecia patients.

research Promotional Effect of Platelet-Rich Plasma on Hair Follicle Reconstitution In Vivo

63 citations, October 2013 in “Dermatologic Surgery”

Platelet-Rich Plasma (PRP) increases the number of new hair follicles and speeds up hair formation.

A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations, April 2013 in “British Journal of Dermatology”

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

research Platelet-Rich Plasma Injection Is Effective and Safe for the Treatment of Alopecia

45 citations, March 2013 in “European Journal of Plastic Surgery”

Injecting platelet-rich plasma is a safe and effective way to treat hair loss.

research The Effect of CD34+ Cell-Containing Autologous Platelet-Rich Plasma Injection on Pattern Hair Loss: A Preliminary Study

88 citations, December 2012 in “Journal of The European Academy of Dermatology and Venereology”

Injecting CD34+ cell-containing platelet-rich plasma into the scalp can improve hair count and thickness in people with pattern hair loss.

research Letter: Platelet-Rich Plasma for Treating Male Pattern Baldness

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Injecting platelet-rich plasma (PRP) can increase hair growth rate and density in male pattern baldness.

research Pattern Hair Loss in Men: Diagnosis, Genetic Link, Clinical Features, and Treatments

58 citations, September 2012 in “Dermatologic Clinics”

Male pattern hair loss caused by follicular miniaturization; early diagnosis and treatment can reduce psychological burden.

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270 citations, March 2012 in “Dermatologic Surgery”

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

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Platelet-rich plasma with a new carrier significantly increases hair thickness without serious side effects.

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The document concludes that minoxidil and finasteride are proven for hair growth, herbal remedies show promise, but more research is needed to confirm their effectiveness.

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42 citations, March 2010 in “Endocrinology”

Mice with human gene experienced hair loss when treated with DHT.

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51 citations, February 2009 in “Journal of dermatological science”

Pitx2 helps outer root sheath cells differentiate but can't start hair growth on its own.

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Minoxidil and ATRA together boost hair growth more effectively than minoxidil alone.

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Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.

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