A Mouse Model of Androgenetic Alopecia

March 2010 in “ Endocrinology ”

Judy S. Crabtree, Edward J. Kilbourne, Bryan J. Peano, Susan Chippari, Thomas E. Kenney, Christopher A. McNally, Wei Wang, Heather A. Harris, Richard C. Winneker, Sunil Nagpal, Catherine Thompson

androgenetic alopecia transgenic mouse androgen receptor keratin 5 promoter beta-catenin dihydrotestosterone hair loss AGA AR DHT

TLDR Mice with human gene experienced hair loss when treated with DHT.

This scientific paper from 13 years ago describes the creation of a mouse model of androgenetic alopecia (AGA), a common form of hair loss in humans. The researchers used a transgenic mouse with a human androgen receptor (AR) gene inserted under the control of a human keratin 5 promoter. They found that the AR gene interacted with beta-catenin, a protein involved in hair growth, and that treatment with dihydrotestosterone (DHT) led to hair loss in the transgenic mice. The study provides a useful tool for studying the mechanisms of AGA and potential treatments.

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