Androgenetic Alopecia: In Vivo Models

October 1999 in “ Experimental and Molecular Pathology ”

John P. Sundberg, Wesley G. Beamer, Hideo Uno, Dominque Van Neste, Lloyd E. King

androgenetic alopecia rodent models human skin grafts stump-tailed macaque hair loss animal models new therapies hair loss

TLDR Stump-tailed macaque best for researching hair loss causes and treatments.

This document explores various in vivo models for studying androgenetic alopecia, including rodent models, human skin grafts to mice, and the stump-tailed macaque. The stump-tailed macaque is the most commonly used and useful model. These models offer opportunities for researching the causes and treatment of this type of hair loss. The paper also discusses the use of animal models to study and test new therapies for androgenetic alopecia.

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Research cited in this study

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research Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts

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The document concludes that certain rats and mice are useful for studying hair loss in humans and testing treatments.

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Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.

research Alopecia Areata in Aging C3H/HeJ Mice

178 citations , June 1994 in “Journal of Investigative Dermatology”

Alopecia areata in these mice is inherited, more common in young females, and can be treated with triamcinolone acetonide.

The Importance of Adequate Serum Ferritin Levels During Oral Cyproterone Acetate and Ethinyl Estradiol Treatment of Diffuse Androgen-Dependent Alopecia in Women

research The Importance of Adequate Serum Ferritin Levels During Oral Cyproterone Acetate and Ethinyl Estradiol Treatment of Diffuse Androgen-Dependent Alopecia in Women

83 citations , April 1992 in “Clinical Endocrinology”

Having enough iron improves the effectiveness of a specific hair loss treatment in women.

research Reduced Linear Hair Growth Rates of Vellus and Terminal Hairs Produced by Human Balding Scalp Grafted onto Nude Mice

23 citations , December 1991 in “Annals of the New York Academy of Sciences”

Balding scalps slow down hair growth.

Biochemical and Trichological Characterization of Diffuse Alopecia in Women

Related Research

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research Androgenetic Alopecia: In Vivo Models

27 citations , October 1999 in “Experimental and Molecular Pathology”

Stump-tailed macaque best for researching hair loss causes and treatments.

Androgenetic Alopecia: In Vivo Models

Research cited in this study

research Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts

research Comparison of Alopecia Areata in Human and Nonhuman Mammalian Species

research Hair Problems in Women: A 1997 Study on Prevalence, Psychological Impact, and Treatment Approaches

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

research Alopecia Areata in Aging C3H/HeJ Mice

research The Importance of Adequate Serum Ferritin Levels During Oral Cyproterone Acetate and Ethinyl Estradiol Treatment of Diffuse Androgen-Dependent Alopecia in Women

research Reduced Linear Hair Growth Rates of Vellus and Terminal Hairs Produced by Human Balding Scalp Grafted onto Nude Mice

research Biochemical and Trichological Characterization of Diffuse Alopecia in Women

research The Effects of Topical Diazoxide on Hair Follicular Growth and Physiology of the Stumptailed Macaque

research Animal Models of Androgen-Dependent Disorders of the Pilosebaceous Apparatus

research The Effect of Testosterone, Cyproterone Acetate, and Minoxidil on Hair Loss in Androgenetic Alopecia Mouse

research Action of Topical Minoxidil in the Bald Stump-Tailed Macaque

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