131 citations
,
November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that alopecia areata can be induced and serially transferred in C3H/HeJ mice using skin grafts, providing a useful model for studying the disease in humans.
412 citations
,
January 1998 in “Science” This study identified a missense mutation in the human hairless gene associated with a rare form of recessively inherited alopecia universalis, pinpointed on chromosome 8p12.
71 citations
,
January 1998 in “Pathobiology” This review discusses the use of animal models to study alopecia areata and reports no new experimental results, emphasizing the potential for these models to explore the disease's genetics and treatment.
37 citations
,
January 1997 in “Clinics in Dermatology” This study found that women with androgenetic alopecia and alopecia areata had significantly lower serum ferritin levels compared to women without hair loss.
33 citations
,
January 1997 in “Endocrinology” Testosterone was found to inhibit hair follicle epithelial cell proliferation in adult stumptailed macaques only when dermal papilla cells from bald scalps were present, and this effect was reversed by the antiandrogen RU 58841.
28 citations
,
January 1996 in “Skin Pharmacology and Physiology” This study observed that minoxidil specifically increased DNA synthesis in hair follicle cells, suggesting its distinct mechanism of action in promoting hair growth compared to cyclosporin, which showed no direct proliferative effect on these cells.
178 citations
,
June 1994 in “Journal of Investigative Dermatology” This study found that a non-scarring alopecia in C3H/HeJ mice resembles human alopecia areata and may serve as a valuable model for studying specific subtypes of the human condition.
83 citations
,
April 1992 in “Clinical Endocrinology” This study found that treatment with cyproterone acetate and ethinyl oestradiol increased hair density in women with diffuse androgen-dependent alopecia, particularly when serum ferritin levels were above 40 μg/l.
60 citations
,
February 1992 in “British Journal of Dermatology” In this study, serum from patients with alopecia areata or universalis did not affect hair growth in transplanted scalp skin grafts on nude mice, despite increased deposition of immunoreactants.
23 citations
,
December 1991 in “Annals of the New York Academy of Sciences” This study reported that human balding scalp grafted onto nude mice showed reduced linear growth rates of both vellus and terminal hairs.
124 citations
,
August 1990 in “British Journal of Dermatology” Diffuse alopecia in women may be related to androgens and iron deficiency, and basic hormone and nutrient screening is useful.
11 citations
,
May 1990 in “Journal of Dermatological Science” In this animal study, topical diazoxide treatment led to increased hair thickness and follicle growth in bald stumptailed macaques without causing notable systemic side effects.
38 citations
,
July 1989 in “Archives of dermatological research” Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.
12 citations
,
October 1988 in “Clinics in dermatology” This report introduces a mouse model with androgen-dependent alopecia, suggesting it as a potential alternative for studying hair loss mechanisms and testing treatments.
78 citations
,
March 1987 in “Journal of The American Academy of Dermatology” Minoxidil promotes hair growth but stops working when discontinued.
203 citations
,
November 1984 in “Journal of the American Academy of Dermatology” This study presents evidence suggesting that androgenetic alopecia is most likely inherited through a polygenic model, challenging the traditional view that it is caused by a simple Mendelian autosomal dominant gene.
