Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway

May 2020 in “ Stem Cell Research & Therapy ”

Tiechao Jiang, Zhongyu Wang, Ji Sun

mesenchymal stem cell-derived exosomes cutaneous wound healing TGF-β/Smad signaling pathway keratinocytes dermal fibroblasts TGF-β1 Smad2 Smad3 Smad4 TGF-β3 Smad7

TLDR Exosomes from stem cells help wounds heal faster by affecting specific cell signals.

The study investigated the effects of human bone marrow mesenchymal stem cell-derived exosomes (hBM-MSC-Ex) on cutaneous wound healing in rats, demonstrating that hBM-MSC-Ex significantly accelerated wound healing and improved skin regeneration, including the restoration of hair follicles and sebaceous glands. The treatment enhanced angiogenesis and modulated the TGF-β/Smad signaling pathway, downregulating TGF-β1, Smad2, Smad3, and Smad4, while upregulating Smad7 and TGF-β3. In vivo, hBM-MSC-Ex treatment led to a significant reduction in wound area and complete healing by day 16, outperforming the PBS control group. These findings suggested that hBM-MSC-Ex could be a promising cell-free therapeutic strategy for enhancing skin regeneration and treating cutaneous wounds, offering potential for scar-less healing.

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