Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway

May 2020 in “ Stem Cell Research & Therapy ”

Tiechao Jiang, Zhongyu Wang, Ji Sun

TLDR Exosomes from stem cells help wounds heal faster by affecting specific cell signals.

The study investigated the effects of human bone marrow mesenchymal stem cell-derived exosomes (hBM-MSC-Ex) on cutaneous wound healing in rats. It was found that hBM-MSC-Ex effectively promoted the growth of human keratinocytes and human dermal fibroblasts, accelerating wound healing. The mechanism involved the modulation of the TGF-β/Smad signaling pathway, where hBM-MSC-Ex downregulated TGF-β1, Smad2, Smad3, and Smad4, while upregulating TGF-β3 and Smad7. These findings suggested that hBM-MSC-Ex could be a promising cell-free therapeutic strategy for treating cutaneous wounds.

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