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GlossarySMAD3

regulates cell growth and differentiation in the TGF-β pathway

SMAD3, also known as Mothers against decapentaplegic homolog 3, is a protein that plays a crucial role in the TGF-β (transforming growth factor-beta) signaling pathway. This pathway is important for regulating cell growth, differentiation, and apoptosis. Mutations or dysregulation of SMAD3 can be associated with various diseases, including cancer and fibrosis, and it has also been implicated in certain forms of alopecia (hair loss).

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Androgen Receptor Transactivity Is Potentiated by TGF-β1 Through Smad3 but Checked by Its Coactivator Hic-5/ARA55 in Balding Dermal Papilla Cells

research Androgen Receptor Transactivity Is Potentiated by TGF-β1 Through Smad3 but Checked by Its Coactivator Hic-5/ARA55 in Balding Dermal Papilla Cells

19 citations , November 2011 in “Journal of Dermatological Science”

TGF-β1 increases androgen receptor activity in hair loss, but Hic-5/ARA55 can counter this effect.

research Decorin-Mediated Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Growth and Development Through miR-129-2-3p/SMAD3/TGF-β Axis

January 2025 in “International Journal of Biological Macromolecules”

Decorin helps hair growth by influencing specific cell signals.

iTRAQ-Based Quantitative Proteomics Revealing the Therapeutic Mechanism of a Medicinal and Edible Formula YH0618 in Reducing Doxorubicin-Induced Alopecia by Targeting Keratins and TGF-β/Smad3 Pathway

research iTRAQ-Based Quantitative Proteomics Revealing the Therapeutic Mechanism of a Medicinal and Edible Formula YH0618 in Reducing Doxorubicin-Induced Alopecia by Targeting Keratins and TGF-β/Smad3 Pathway

June 2024 in “Heliyon”

YH0618 helps reduce chemotherapy-induced hair loss by targeting specific proteins and pathways.

research Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway

March 2023 in “International Journal of Molecular Sciences”

ADSC-Exos with miR-122-5p can help treat hair loss by promoting hair growth.

research Epithelial–Mesenchymal Transition in Keloid Tissues and TGF-β1–Induced Hair Follicle Outer Root Sheath Keratinocytes

46 citations , July 2015 in “Wound repair and regeneration”

Keloid scars may form due to changes in skin cell characteristics and specific protein signaling.

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community Dr Gokhan Gur. 2nd HT - 1849 grafts. Focus on midscalp and crown

in Transplants 7 upvotes 4 months ago

A user shared their experience with a second hair transplant by Dr. Gokhan Gur, focusing on the midscalp and crown with 1849 grafts. Their current treatment includes dutasteride, finasteride, oral and topical minoxidil, and Nizoral shampoo.

community What's your option on complementary treatment

in Product 3 upvotes 1 year ago

The conversation discusses complementary treatments for hair loss while using finasteride and minoxidil, including scalp massagers, scrubs, coconut oil, and vitamin supplements. The user seeks opinions on these additional treatments.

community 9 months dut results Sept 2023- today

in Progress Pictures 41 upvotes 1 year ago

The user has been taking dutasteride for 9 months and is satisfied with the hair growth results. They had a hair transplant and don't want to share hairline progress.

community Creatine's effect on Hair Loss and DHT

in Research/Science 100 upvotes 1 year ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

community Creatine Does Not Increase DHT And Does Not Cause Hair Loss - Randomized Controlled Trial

in Research/Science 307 upvotes 4 months ago

Creatine does not increase DHT levels or cause hair loss. Personal experiences vary, but scientific evidence shows no link between creatine and hair loss.