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GlossarySMAD3

regulates cell growth and differentiation in the TGF-β pathway

SMAD3, also known as Mothers against decapentaplegic homolog 3, is a protein that plays a crucial role in the TGF-β (transforming growth factor-beta) signaling pathway. This pathway is important for regulating cell growth, differentiation, and apoptosis. Mutations or dysregulation of SMAD3 can be associated with various diseases, including cancer and fibrosis, and it has also been implicated in certain forms of alopecia (hair loss).

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Androgen Receptor Transactivity Is Potentiated by TGF-β1 Through Smad3 but Checked by Its Coactivator Hic-5/ARA55 in Balding Dermal Papilla Cells

research Androgen Receptor Transactivity Is Potentiated by TGF-β1 Through Smad3 but Checked by Its Coactivator Hic-5/ARA55 in Balding Dermal Papilla Cells

19 citations , September 2011 in “Journal of Dermatological Science”

TGF-β1 increases androgen receptor activity in hair loss, but Hic-5/ARA55 can counter this effect.

research Decorin-Mediated Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Growth and Development Through miR-129-2-3p/SMAD3/TGF-β Axis

January 2025 in “International Journal of Biological Macromolecules”

Decorin helps hair growth by influencing specific cell signals.

iTRAQ-Based Quantitative Proteomics Revealing the Therapeutic Mechanism of a Medicinal and Edible Formula YH0618 in Reducing Doxorubicin-Induced Alopecia by Targeting Keratins and TGF-β/Smad3 Pathway

research iTRAQ-Based Quantitative Proteomics Revealing the Therapeutic Mechanism of a Medicinal and Edible Formula YH0618 in Reducing Doxorubicin-Induced Alopecia by Targeting Keratins and TGF-β/Smad3 Pathway

June 2024 in “Heliyon”

YH0618 helps reduce chemotherapy-induced hair loss by targeting specific proteins and pathways.

research Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway

March 2023 in “International Journal of Molecular Sciences”

ADSC-Exos with miR-122-5p can help treat hair loss by promoting hair growth.

research The Roles of Smad2 and Smad3 in Mouse Skin Development

June 2008 in “The Knowledge Bank (The Ohio State University)”

Smad2 and Smad3 are essential for normal skin development, and their absence causes severe skin issues and cancer.

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community Dr Gokhan Gur. 2nd HT - 1849 grafts. Focus on midscalp and crown

in Transplants 7 upvotes 6 months ago

A user shared their experience with a second hair transplant by Dr. Gokhan Gur, focusing on the midscalp and crown with 1849 grafts. Their current treatment includes dutasteride, finasteride, oral and topical minoxidil, and Nizoral shampoo.

community What's your option on complementary treatment

in Product 3 upvotes 1 year ago

The conversation discusses complementary treatments for hair loss while using finasteride and minoxidil, including scalp massagers, scrubs, coconut oil, and vitamin supplements. The user seeks opinions on these additional treatments.

community 9 months dut results Sept 2023- today

in Progress Pictures 41 upvotes 1 year ago

The user has been taking dutasteride for 9 months and is satisfied with the hair growth results. They had a hair transplant and don't want to share hairline progress.

community Creatine's effect on Hair Loss and DHT

in Research/Science 99 upvotes 1 year ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

community Haircafe video on Min Sulfate, thoughts?

in Research/Science 101 upvotes 2 weeks ago

Minoxidil sulfate is considered for those unresponsive to regular minoxidil, with some trying a 10% formulation from Folligenz. Concerns exist about the product's stability and transparency, but some users report positive initial results.

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