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    Glossary SMAD3

    regulates cell growth and differentiation in the TGF-β pathway

    SMAD3, also known as Mothers against decapentaplegic homolog 3, is a protein that plays a crucial role in the TGF-β (transforming growth factor-beta) signaling pathway. This pathway is important for regulating cell growth, differentiation, and apoptosis. Mutations or dysregulation of SMAD3 can be associated with various diseases, including cancer and fibrosis, and it has also been implicated in certain forms of alopecia (hair loss).

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    1. Human bone marrow mesenchymal stem cell-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway Stem Cell Research & Therapy · 2020 · 139 citations
    2. Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes Nucleic Acids Research · 2002 · 79 citations
    3. The 800-nm diode laser irradiation induces skin collagen synthesis by stimulating TGF-β/Smad signaling pathway Lasers in Medical Science · 2011 · 59 citations
    4. Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells Molecular biology of the cell · 2008 · 43 citations
    5. Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity Developmental Biology · 2008 · 28 citations
    6. Androgen receptor transactivity is potentiated by TGF-β1 through Smad3 but checked by its coactivator Hic-5/ARA55 in balding dermal papilla cells Journal of Dermatological Science · 2011 · 19 citations
    7. Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes Plastic and Reconstructive Surgery · 2007 · 16 citations
    8. Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma Oncotarget · 2018 · 11 citations
    9. All-trans-retinoic acid inhibits mink hair follicle growth via inhibiting proliferation and inducing apoptosis of dermal papilla cells through TGF-β2/Smad2/3 pathway Acta histochemica · 2020 · 10 citations
    10. miR-370-3p Inhibited the Proliferation of Sheep Dermal Papilla Cells by Inhibiting the Expression of SMAD4 Cells · 2025 · 4 citations
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    Community 2

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