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Glossary SMAD proteins

proteins that transmit signals from cell surface to nucleus

SMAD proteins are a group of molecules that play a crucial role in transmitting signals from the cell surface to the nucleus. They are involved in the TGF-beta signaling pathway, which regulates various cellular processes such as growth, differentiation, and apoptosis. Essentially, they act as messengers that help cells respond to external signals, ensuring proper cellular function and development.

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research Aconiti Lateralis Preparata Radix Activates the Proliferation of Mouse Bone Marrow Mesenchymal Stem Cells and Induces Osteogenic Lineage Differentiation through the Bone Morphogenetic Protein-2/Smad-Dependent Runx2 Pathway

18 citations , January 2013 in “Evidence-based Complementary and Alternative Medicine”

In this study, ALR was found to enhance both the proliferation and osteogenic differentiation of mouse bone marrow mesenchymal stem cells, potentially through specific signaling pathways.

research Data from Elevated Cutaneous Smad Activation Associates with Enhanced Skin Tumor Susceptibility in Organ Transplant Recipients

March 2023

This study found significantly higher P-Smad2 levels in both lesional and nonlesional skin of organ transplant recipients, suggesting elevated TGF-β signaling might contribute to their increased cancer susceptibility.

research Transforming growth factor-β in stem cells and tissue homeostasis

245 citations , January 2018 in “Bone Research”

This review discusses the role of TGF-β signaling in stem cell recruitment and tissue regeneration, indicating that abnormalities in TGF-β activation contribute to various major diseases and suggesting avenues for therapeutic intervention.

research TGF-β Family Signaling in Epithelial Differentiation and Epithelial–Mesenchymal Transition

82 citations , February 2017 in “Cold Spring Harbor Perspectives in Biology”

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

research Preliminary study on microR-148a and microR-10a in dermal papilla cells of Hu sheep

28 citations , August 2019 in “BMC Genetics”

This study identified a target relationship between miR-148a, miR-10a, and BMP7, suggesting these microRNAs influence dermal papilla cell proliferation and may regulate hair follicle growth.

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community My Theory Of Androgenic Alopecia

16 upvotes 10 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community What foods do you feel have helped you get essential nutrients?

1 upvotes 8 months ago

Common foods that may support hair growth include ginger shots, salmon, roasted chicken, spinach, tinned sardines, and grass-fed ground beef. Energy drinks are considered bad, and iced coffee is suggested as a possible alternative.

community Creatine's effect on Hair Loss and DHT

103 upvotes 2 years ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

community How do athletes maintain their hair transplants? Or do they not?

in Transplants 57 upvotes 1 year ago

Athletes often use finasteride to maintain hair transplants, but some avoid it due to potential hormonal effects. Notable examples include Mo Salah and Conor McGregor, while LeBron James has had multiple procedures with varying success.

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