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    Glossary SMAD4

    protein involved in TGF-beta signaling, affecting cell growth and differentiation

    SMAD4, also known as Mothers against decapentaplegic homolog 4, is a protein that plays a crucial role in the TGF-beta signaling pathway, which is involved in regulating cell growth, differentiation, and apoptosis. Mutations in the SMAD4 gene can lead to various medical conditions, including certain types of cancer and hereditary hemorrhagic telangiectasia.

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    1. Smad7-Induced β-Catenin Degradation Alters Epidermal Appendage Development Developmental Cell · 2006 · 147 citations
    2. Human bone marrow mesenchymal stem cell-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway Stem Cell Research & Therapy · 2020 · 139 citations
    3. Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes Nucleic Acids Research · 2002 · 79 citations
    4. Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells Molecular biology of the cell · 2008 · 43 citations
    5. Smad1 and 5 but Not Smad8 Establish Stem Cell Quiescence Which Is Critical to Transform the Premature Hair Follicle During Morphogenesis Toward the Postnatal State Stem Cells · 2013 · 31 citations
    6. Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity Developmental Biology · 2008 · 28 citations
    7. Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes Plastic and Reconstructive Surgery · 2007 · 16 citations
    8. The up‐regulation of 14‐3‐3 proteins in Smad4 deficient epidermis and hair follicles at catagen PROTEOMICS · 2008 · 14 citations
    9. Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma Oncotarget · 2018 · 11 citations
    10. miR-370-3p Inhibited the Proliferation of Sheep Dermal Papilla Cells by Inhibiting the Expression of SMAD4 Cells · 2025 · 4 citations
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